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RASSF1 was significantly over expressed in infarcted myocardial tissues as well as in cardiomyocytes induced by hypoxia. Inhibition of RASSF1 expression alleviated cardiomyocytes apoptosis induced by hypoxia in vitro and reduced cardiomyocytes apoptosis after AMI in vivo. RASSF1 expression was directly modulated by miR\u2010125b, which was further confirmed by luciferase reporter assay. The current study verified that the miR\u2010125b\/RASSF1 axis was involved in cardiomyocytes apoptosis. To sum up, these results suggest that RASSF1 downregulation alleviated infarction\u2010induced cardiomyocytes apoptosis and was regulated by miR\u2010125b.<\/jats:p>","DOI":"10.1002\/jcb.29236","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T06:51:58Z","timestamp":1570603918000},"page":"489-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["RASSF1 promotes cardiomyocyte apoptosis after acute myocardial infarction and is regulated by miR\u2010125b"],"prefix":"10.1002","volume":"121","author":[{"given":"Bai","family":"Xiaochuan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine of the First People's Hospital of Zunyi City  Guizhou 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