{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:09:19Z","timestamp":1780103359833,"version":"3.54.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601804"],"award-info":[{"award-number":["81601804"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772209"],"award-info":[{"award-number":["81772209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chemerin, a chemoattractant protein, is involved in endothelial dysfunction and vascular inflammation in pathological conditions. In a recent study, we observed the upregulation of chemerin in endothelial cells following in vitro treatment with\n                    <jats:italic>Treponema pallidum<\/jats:italic>\n                    . Here, we investigated the role of chemerin in endothelial cells activation induced by the\n                    <jats:italic>T. pallidum<\/jats:italic>\n                    predicted membrane protein Tp0965. Following stimulation of human umbilical vein endothelial cells (HUVECs) with Tp0965, chemerin and its receptor chemerin receptor 23 (ChemR23) were upregulated, companied with elevated expression of Toll\u2010like receptor 2. Furthermore, chemerin from HUVECs activated endothelial cells via chemerin\/ChemR23 signaling in an autocrine\/paracrine manner, characterized by upregulated expression of intercellular adhesion molecule 1, E\u2010selectin, and matrix metalloproteinase\u20102. Activation of endothelial cells depended on the mitogen\u2010activated protein kinase signaling pathway. In addition, Tp0965\u2010induced chemerin promoted THP\u20101\u2010derived macrophages migration to endothelial cells, also via the chemerin\/ChemR23 pathway. The RhoA\/ROCK signaling pathway was also involved in THP\u20101\u2010derived macrophages migration in response to chemerin\/ChemR23. Our results highlight the role of Tp0965\u2010induced chemerin in endothelial cells dysfunction, which contributes to the immunopathogenesis of vascular inflammation of syphilis.\n                  <\/jats:p>","DOI":"10.1002\/jcb.29269","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T09:08:34Z","timestamp":1563527314000},"page":"19621-19634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chemerin induced by\n                    <i>Treponema pallidum<\/i>\n                    predicted membrane protein Tp0965 mediates the activation of endothelial cell via MAPK signaling pathway"],"prefix":"10.1002","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7364-4649","authenticated-orcid":false,"given":"Rui\u2010Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Qiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Chinese Academy of Medical Science &amp; Peking Union Medical College, &amp; National Center for STD Control China Centers for Disease Control and Prevention  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Jia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"e_1_2_7_1_2_1","unstructured":"World Health Organization.Global incidence and prevalence of selected sexually transmitted infections\u20132008. 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