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Serum microRNAs (miRNAs) are currently considered to be valuable as noninvasive cancer biomarkers, but their role in the prognosis of cervical cancer has not been elucidated. We aimed to find serum miRNAs that can be used as prognostic factors for cervical cancer. A traumatic pathological biopsy is the only reliable method for determining the severity of cervical cancer currently. Thus, noninvasive diagnostic markers are needed. The serological expression of candidate miRNAs were measured in 90 participants, including 60 patients with\u00a0cervical cancer and 50 patients with cervical intraepithelial neoplasia. Two patients with\u00a0cervical cancer were excluded from the study because of lack of data. miRNAs were evaluated by quantitative reverse transcription polymerase chain reaction. miR\u2010143\/\u22124636 appeared specific for cervical cancer compared with cervical intraepithelial neoplasia (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The classification performance of validated miRNAs for cervical cancer [Area under the receiver operating characteristic curve (AUC)\u2009=\u20090.942] was better than that reached by squamous cell carcinoma antigen (SCC\u2010Ag; AUC\u2009=\u20090.727). Poor\u2010differentiation group has lower miR\u2010143\/\u22124636 levels in serum (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). miR\u20104636 level was correlated gross tumor volume and the depth of invasion (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). In our study, we found a combination of miR\u2010143 and miR\u20104636 that is independently and strongly associated with cervical cancer prognosis and can be used as a clinically prognostic factor.<\/jats:p>","DOI":"10.1002\/jcb.29305","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T05:49:25Z","timestamp":1565675365000},"page":"596-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Peripheral blood circulating microRNA\u20104636\/\u2212143 for the prognosis of cervical cancer"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7253-2191","authenticated-orcid":false,"given":"Sheng","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The Second Xiangya Hospital of Central South University Changsha Hunan P.R. 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