{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:19:15Z","timestamp":1775672355587,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi","doi-asserted-by":"publisher","award":["S201655"],"award-info":[{"award-number":["S201655"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi","doi-asserted-by":"publisher","award":["S201668"],"award-info":[{"award-number":["S201668"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2015GXNSFBA139158"],"award-info":[{"award-number":["2015GXNSFBA139158"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2017GXNSFAA198258"],"award-info":[{"award-number":["2017GXNSFAA198258"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2018GXNSFAA050082"],"award-info":[{"award-number":["2018GXNSFAA050082"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2018JJA140912"],"award-info":[{"award-number":["2018JJA140912"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560371"],"award-info":[{"award-number":["81560371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760390"],"award-info":[{"award-number":["81760390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760402"],"award-info":[{"award-number":["81760402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Current research suggests that synovial phagocytic cells remove excessive amounts of free oxygen radicals (reactive oxygen species [ROS]), thereby preventing damage to synovial tissues. Moreover, ROS may affect the expression of growth arrest and DNA damage inducible \u03b1 (GADD45A), thus further promoting the activation of synovial fibroblasts. Male adult rats were assessed for progression of collagen\u2010induced arthritis (CIA) using a macroscopic arthritis scoring system of the hind paws and by measuring the changes in the rat's body weight, and activity level before and after diagnosis of CIA. Rats were intraperitoneally injected twice daily with edaravone at doses of 3, 6, and 9\u2009mL\/kg. Samples were taken at 2, 4, and 6 weeks, respectively. Edaravone was found to significantly reduce macroscopic arthritis and microscopic pathology scores in CIA rats. The concentration of endothelial nitric oxide synthase\u20106, glutathione, and heme oxygenase\u20101 in the serum of rats decreased, as was the production of ROS around the synovium and inflammatory factors. Moreover, ROS\u20101 increased the expression of the nuclear factor\u2010\u03baB (NF\u2010\u03baB) p65 protein by altering the expression level of GADD45A, causing aggravation of tissue damage. Edaravone also significantly improved the physiological condition of CIA rats, including appetite, weight changes, and loss of fur, as well as limb mobility. We believe that edaravone acts to reduce the expression of NF\u2010\u0138B p65 by clearing ROS, which causes reduced expression of GADD45A, and subsequently reduces the level of apoptosis and inflammatory response proteins, thereby reducing the symptoms of CIA. We, therefore, propose that edaravone is an effective option for clinical treatment of rheumatic arthritis.<\/jats:p>","DOI":"10.1002\/jcb.29382","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T01:15:05Z","timestamp":1570670105000},"page":"1463-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The therapeutic effects of edaravone on collagen\u2010induced arthritis in rats"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7964-3938","authenticated-orcid":false,"given":"Xiaohan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics Trauma and Hand Surgery, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guihong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Hand Surgery, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Hand Surgery, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Bone and Joint Surgery, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"},{"name":"Guangxi Collaborative Innovation Center for Biomedicine Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Trauma and Hand Surgery, Guangxi Medical University First Affiliated Hospital Guangxi Medical University  Nanning China"},{"name":"Guangxi Collaborative Innovation Center for Biomedicine Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.026"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw5422"},{"key":"e_1_2_6_1_4_1","volume-title":"Goldman's Cecil Medicine","author":"Goldman L","year":"2011"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.05.007"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox6030051"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2484678"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27421"},{"key":"e_1_2_6_1_9_1","first-page":"231","article-title":"Anti\u2010CCP antibodies, rheumatoid factors and anti\u2010keratin antibodies: clinical value in established rheumatoid arthritis","volume":"89","author":"Amri M","year":"2011","journal-title":"Tunis Med"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215428"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21776"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24054"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.164"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.13"},{"key":"e_1_2_6_1_15_1","first-page":"121","article-title":"The free radical scavenger edaravone suppresses experimental closed duodenal loop\u2010induced acute pancreatitis in rats","volume":"12","author":"Araki Y","year":"2003","journal-title":"Int J Mol Med"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.12.006"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.05.020"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480527"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes113"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2005.03.009"},{"issue":"5","key":"e_1_2_6_1_21_1","first-page":"6799","article-title":"Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast\u2010like synoviocytes","volume":"120","author":"Li Y","year":"2018","journal-title":"J Cell Biochem"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.10.016"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.02.006"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28514"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.01.005"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110242"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.746"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14023834"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.29382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.29382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.29382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:15:38Z","timestamp":1772961338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.29382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,9]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jcb.29382"],"URL":"https:\/\/doi.org\/10.1002\/jcb.29382","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,9]]},"assertion":[{"value":"2019-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}