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The aim of this study was to determine their potential oncogenic role .in tongue squamous cell carcinoma (TSCC). We detected significantly higher expression levels of both PD\u2010L1 and BRD4 in TSCC tissues compared to normal tissues (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u2009.05). In addition, the high levels of PD\u2010L1 were significantly associated with increased tumor lymphatic metastasis (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u2009.05), tumor staging (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u2009.01), as well as BRD4 expression (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u2009.05). Genetic and pharmacological inhibition of BRD4 in TSCC cells not only reduced their growth rate but also PD\u2010L1 levels (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u2009.05), while overexpression of BRD4 upregulated PD\u2010L1. Bioinformatics analysis showed that c\u2010MYC and CDK9 were interactive partners of both BRD4 and PD\u2010L1. While c\u2010MYC clearly modulated the expression of PD\u2010L1, as well as reversed the inhibitory effects of JQ1, no obvious association was observed between CDK9 and PD\u2010L1. We report a novel regulatory axis consisting of BRD4, PD\u2010L1, and c\u2010MYC that likely drives TSCC progression, and is a potential prognostic marker and\/or therapeutic target for TSCC.\n                  <\/jats:p>","DOI":"10.1002\/jcb.29420","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T10:20:38Z","timestamp":1571653238000},"page":"1855-1869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Expression and clinical value of PD\u2010L1 which is regulated by BRD4 in tongue squamous cell carcinoma"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2417-9247","authenticated-orcid":false,"given":"Lu","family":"Zhao","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology Shandong University  Jinan Shandong China"},{"name":"Department of Oral and Maxillofacial Surgery, School of Stomatology Shandong University  Jinan Shandong China"},{"name":"Department of Stomatology Binzhou People's Hospital  Binzhou Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengchong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Binzhou People's Hospital  Binzhou Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Periodontology Dongguan Dental Hospital  Dongguan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Stomatology Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Oral and 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