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The purpose of the study was to identify the regulatory mechanism of the nucleus accumbens (NAc) in heroin dependence. We used weighted gene co\u2010expression network analysis to analyze the GSE87823 data package, which included 27 heroin users and 22 controls of human NAc tissue. Modules were correlated with basic information of samples and enrichment analyses used to identify biological function and transcription factors and online tools were used to perform the gene ontology of significant genes. We identified one gene module from the total data (blue) and the male data (turquoise), respectively. The overlap genes of top 10 hub genes in significant modules (PRR11, SLC35E1, LPP, ZNF721, ZNF611, LRRFIP1) were selected to identify as candidate genes in the regulation mechanism of NAc in heroin dependence. Then, we accorded the results to further explore\u00a0that\u00a0miRNA\u2010hsa\u2010miR\u2010155\u20105p in male and total may be a\u00a0potential marker. 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Hsa\u2010miR\u2010155\u20105p may be a promising regulatory point for the treatment of heroin addiction.<\/jats:p>","DOI":"10.1002\/jcb.29422","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T07:48:57Z","timestamp":1573026537000},"page":"1870-1879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Weighted gene co\u2010expression network analysis to explore the mechanism of heroin addiction in human nucleus accumbens"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5830-7759","authenticated-orcid":false,"given":"Xugang","family":"Shi","sequence":"first","affiliation":[{"name":"Key Laboratory of Environment and Genes Related to Diseases Xi'an Jiaotong University, Ministry of Education  Xi'an China"},{"name":"College of Forensic Science, Key Laboratory of Public Health for Forensic Science Xi'an Jiaotong University  Xi'an 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