{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:26:07Z","timestamp":1772983567989,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Long noncoding RNAs (lncRNAs) play an indispensable role in cancer progression. We aim at exploring the effect of AC009022.1 on colorectal cancer (CRC) development in this paper.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CRC tissues and matched normal tissues of 68 CRC patients were collected. HCT\u2010116 and SW620 cells were transfected and grouped. The cell counting kit\u20108 assay, cell scratch test, and Transwell experiment were performed to sequentially detect cells proliferation, migration, and invasion. In vivo experiments were conducted. The Luciferase reporter gene assay was used. Gene expression was detected by quantitative reverse transcription polymerase chain reaction and Western blot analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      AC009022.1 expression was abnormally elevated in CRC tissues and cells. High AC009022.1 expression in CRC patients was significantly associated with poor prognosis. Compared with the siNC group, HCT\u2010116 and SW620 cells of siAC009022.1 group exhibited much lower OD\n                      <jats:sub>450<\/jats:sub>\n                      value (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and invasive cell number (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01), and significantly higher relative wound width (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Much lower subcutaneous tumor volume and weight were found in the siAC009022.1 group compared with siNC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). In CRC cells, AC009022.1 directly inhibited miR\u2010497\u20105p expression while miR\u2010497\u20105p directly hindered ACTR3B expression. Compared with HCT\u2010116 and SW620 cells of oe\u2010AC009022.1 group, those of oe\u2010AC009022.1\u2009+\u2009miR\u2010497\u20105p\u2010mimics group and oe\u2010AC009022.1\u2009+\u2009siACTR3B group had obviously lower OD\n                      <jats:sub>450<\/jats:sub>\n                      value (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and invasion cell number (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01), and markedly higher relative wound width (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AC009022.1 enhanced CRC cell proliferation, migration, and invasion by promoting ACTR3B expression via suppressing miR\u2010497\u20105p.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcb.29428","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T01:29:38Z","timestamp":1571707778000},"page":"1934-1944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["LncRNA AC009022.1 enhances colorectal cancer cells proliferation, migration, and invasion by promoting ACTR3B expression via suppressing miR\u2010497\u20105p"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-0257","authenticated-orcid":false,"given":"Chen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Anus &amp; Intestine Surgery Weifang People's Hospital  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-6098","authenticated-orcid":false,"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anus &amp; Intestine Surgery Weifang People's Hospital  Weifang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_8_1_2_1","first-page":"3587","article-title":"miR\u2010329 regulates the sensitivity of 5\u2010FU in chemotherapy of colorectal cancer by targeting E2F1","volume":"16","author":"Yin J","year":"2018","journal-title":"Oncol Lett"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.10.003"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.02.021"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.006"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx042"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.10.046"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005615"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-016-0535-1"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6446"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15211"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164590"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4350-x"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.02.123"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.024"},{"key":"e_1_2_8_1_17_1","first-page":"1619","article-title":"Downregulation of the long non\u2010coding RNA XLOC_010588 inhibits the invasion and migration of colorectal cancer","volume":"39","author":"Li Y","year":"2018","journal-title":"Oncol Rep"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.07.026"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3136-5"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11252"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S163335"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-017-0482-8"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00488.x"},{"key":"e_1_2_8_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26012"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18201"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4504-x"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.29428","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.29428","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.29428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:15:31Z","timestamp":1772961331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.29428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,21]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/jcb.29428"],"URL":"https:\/\/doi.org\/10.1002\/jcb.29428","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,21]]},"assertion":[{"value":"2019-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}