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The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant\u2010induced arthritis. Animals were divided into control\/saline, control\/quercetin (5\u2009mg\/kg, 25\u2009mg\/kg, and 50\u2009mg\/kg) arthritis\/saline, and arthritis\/quercetin (5\u2009mg\/kg, 25\u2009mg\/kg, and 50\u2009mg\/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels of aspartate aminotransferase, thiobarbituric acid\u2010reactive substances, and reactive oxygen species; however, only treatment with 25 or 50\u2009mg\/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.<\/jats:p>","DOI":"10.1002\/jcb.29502","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T09:25:09Z","timestamp":1573032309000},"page":"2792-2801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis"],"prefix":"10.1002","volume":"121","author":[{"given":"Renata da Silva Pereira","family":"Saccol","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Centro de Ci\u00eancias da Sa\u00fade Universidade Federal de Santa Maria  Santa Maria RS Brasil"},{"name":"Laborat\u00f3rio de Imunobiologia Experimental e 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