{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:34:48Z","timestamp":1768473288766,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"8-9","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of the study was to explore the genetic effects of bone morphogenetic protein (<jats:italic>BMP2<\/jats:italic>) polymorphisms on the susceptibility to ankylosing spondylitis (AS) in Chinese Han population. The case\u2010control study included 120 AS cases and 110 healthy controls. Hardy\u2010Weinberg equilibrium test was performed in control group. <jats:italic>BMP2<\/jats:italic> rs235768 and rs3178250 polymorphisms were analyzed by polymerase chain reaction and direct sequencing. Additionally, the <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0test was used to estimate association strength between <jats:italic>BMP2<\/jats:italic> genetic polymorphisms and AS susceptibility, and the results were assessed via odds ratio (OR) with the corresponding 95% confidence interval (95%CI). Results adjustment was performed using logistic regression analysis. AA, AT, TT genotype and A, T allele frequencies of <jats:italic>BMP2<\/jats:italic> rs235768 polymorphism presented no significant differences between case and control groups (<jats:italic>P\u2009<\/jats:italic>&gt;\u2009.05 for all). TC genotype of rs3178250 polymorphism showed significantly higher in case group than that in control group (<jats:italic>P\u2009<\/jats:italic>=\u2009.048). After adjusting, TC genotype was a risk factor for AS (OR\u2009=\u20092.095;\u00a095%CI\u2009=\u20091.086\u20104.038;\u00a0<jats:italic>P\u2009<\/jats:italic>=\u2009.027). <jats:italic>BMP2<\/jats:italic> rs3178250 polymorphism may increase individual susceptibility to AS in Chinese Han population.<\/jats:p>","DOI":"10.1002\/jcb.29563","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T10:29:39Z","timestamp":1573554579000},"page":"3935-3940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["BMP2 variants in the risk of ankylosing spondylitis"],"prefix":"10.1002","volume":"121","author":[{"given":"Dengbin","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Orthopedics General Hospital of PLA Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of 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