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This material has been shared in an anonymized fashion to accelerate progress in overcoming lung cancer, the leading cause of cancer death across the world. However, this cell line collection also includes a range of other cancers derived from patient\u2010donated specimens that have been remarkably valuable for other types of cancer and disease research. A comprehensive analysis conducted by the NCI Center for Research Strategy of the 278 cell lines reported in the original Journal of Cellular Biochemistry Supplement, documents that these cell lines and related products have since been used in more than 14\u2009000 grants, and 33\u2009207 published scientific reports. This has resulted in over 1.2 million citations using at least one cell line. Many publications involve the use of more than one cell line, to understand the value of the resource collectively rather than individually; this method has resulted in 2.9 million citations. In addition, these cell lines have been linked to 422 clinical trials and cited by 4700 patents through publications. For lung cancer alone, the cell lines have been used in the research cited in the development of over 70 National Comprehensive Cancer Network clinical guidelines. Finally, it must be underscored again, that patient altruism enabled the availability of this invaluable research resource.<\/jats:p>","DOI":"10.1002\/jcb.29564","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T12:04:30Z","timestamp":1575547470000},"page":"3986-3999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["From clinical specimens to human cancer preclinical models\u2014a journey the NCI\u2010cell line database\u201425 years later"],"prefix":"10.1002","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4648-9177","authenticated-orcid":false,"given":"James L.","family":"Mulshine","sequence":"first","affiliation":[{"name":"Center for Healthy Aging, Department of Internal Medicine Rush University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ujhazy","sequence":"additional","affiliation":[{"name":"Translational Research Program, Division of Cancer Treatment and Diagnosis National Cancer Institute Rockville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Antman","sequence":"additional","affiliation":[{"name":"Center for Research Strategy National Cancer Institute Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Burgess","sequence":"additional","affiliation":[{"name":"Research Analytics Digital Science Cambridge Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Kuzmin","sequence":"additional","affiliation":[{"name":"Translational Research Program, Division of Cancer Treatment and Diagnosis National Cancer Institute Rockville Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Paul A.","family":"Bunn","sequence":"additional","affiliation":[{"name":"University of Colorado Cancer Center University of Colorado Cancer Center Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dana\u2010Farber Cancer Institute Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack A.","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Division of Surgery The University of Texas MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey I.","family":"Pass","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery New York University Langone Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila M.","family":"Ross","sequence":"additional","affiliation":[{"name":"Advocacy Lung Cancer Alliance Annapolis Maryland"},{"name":"Member IASLC Early Detection and Screening Committee Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn R.","family":"Aldige","sequence":"additional","affiliation":[{"name":"Prevent Cancer Foundation Alexandria Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio I.","family":"Wistuba","sequence":"additional","affiliation":[{"name":"Department of Translational Molecular Pathology UT MD Anderson Cancer Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"Minna","sequence":"additional","affiliation":[{"name":"Nancy B. and Jake L. 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