{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:25:45Z","timestamp":1789644345462,"version":"4.0.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The emergence and spread of drug resistance in <jats:italic>Plasmodium falciparum<\/jats:italic>, the parasite causing the most severe form of human malaria, is a major threat to malaria control and elimination programs around the globe. With <jats:italic>P. falciparum<\/jats:italic> having evolved widespread resistance against a number of previously widely used drugs, currently, artemisinin (ART) and its derivatives are the cornerstones of first\u2010line treatments of uncomplicated malaria. However, growing incidences of ART failure reflect the spread of ART\u2010resistant <jats:italic>P. falciparum<\/jats:italic> strains. Despite current efforts to understand the primary cause of ART resistance due to mutations in the <jats:italic>Kelch 13<\/jats:italic> gene (<jats:italic>PfK13<\/jats:italic>), the mechanism underlying ART resistance is still not completely unclear and no feasible strategies to counteract the causes and thereby restoring the efficiency of ART have been developed. We use a polypharmacology approach to identify potential drugs that can be used for the novel purpose (target). Of note, we have designed a multimodal stratagem to identify approved drugs with a potential antimalarial activity using computational drug reprofiling. Our investigations suggest that oxetacaine, simvastatin, repaglinide, aclidinium, propafenone, and lovastatin could be repurposed for malaria control and prevention.<\/jats:p>","DOI":"10.1002\/jcb.29954","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T08:19:46Z","timestamp":1621239586000},"page":"1326-1336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against <i>Plasmodium falciparum<\/i> phosphatidylinositol 3\u2010kinase"],"prefix":"10.1002","volume":"122","author":[{"given":"Kanika","family":"Verma","sequence":"first","affiliation":[{"name":"Division of Vector\u2010Borne Diseases ICMR\u2010National Institute of Research in Tribal Health Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayush K.","family":"Lahariya","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases ICMR\u2010National Institute of Research in Tribal Health Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivangee","family":"Dubey","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases ICMR\u2010National Institute of Research in Tribal Health Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases ICMR\u2010National Institute of Research in Tribal Health Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparup","family":"Das","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases ICMR\u2010National Institute of Research in Tribal Health Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristan A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department CB University of Applied Sciences Mittweida Mittweida Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-6869","authenticated-orcid":false,"given":"Praveen K.","family":"Bharti","sequence":"additional","affiliation":[{"name":"Division of Vector\u2010Borne Diseases ICMR\u2010National Institute of Research in Tribal Health Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.\u00a02019.\u00a0World Malaria Report 2019."},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization.\u00a0World Malaria Report 2020. p. 299."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30261-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21682"},{"key":"e_1_2_9_6_1","unstructured":"BlolandPB World Health Organization. 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