{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:56:05Z","timestamp":1778255765837,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007065","name":"Universit\u00e0 degli Studi di Salerno","doi-asserted-by":"publisher","award":["FARB 2017"],"award-info":[{"award-number":["FARB 2017"]}],"id":[{"id":"10.13039\/501100007065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003852","name":"Regione Campania","doi-asserted-by":"publisher","award":["POR CAMPANIA FESR 2014\u20102020 \u201cSYSTEM INNOVATION FOR CANCER EARLY DIAGNOSIS SICED\u201d"],"award-info":[{"award-number":["POR CAMPANIA FESR 2014\u20102020 \u201cSYSTEM INNOVATION FOR CANCER EARLY DIAGNOSIS SICED\u201d"]}],"id":[{"id":"10.13039\/501100003852","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypoxia and angiogenesis in solid tumors are often strictly linked to the development of fibrotic tissues, a detrimental event that compromises the antitumor immunity. As a consequence, tumor aggressiveness and poor patient prognosis relate to higher incidence of tissue fibrosis and stromal stiffness. The molecular pathways through which normal fibroblasts are converted in cancer\u2010associated fibroblasts (CAFs) have a central role in the onset of fibrosis in tumor stroma, thus emerging as a strategic target of novel therapeutic approaches for cancer disease. Several studies addressed the role of BAG3 in sustaining growth and survival of cancer cell and also shed light on the different mechanisms in which the intracellular protein is involved. More recently, new pieces of evidence revealed a pivotal role of extracellular BAG3 in pro\u2010tumor cell signaling in the tumor microenvironment, as well as its involvement in the development of fibrosis in tumor tissues. Here we report further data showing the presence of the BAG3 receptor (Interferon\u2010induced transmembrane protein [IFITM]\u20102) on the plasma membrane of normal dermal fibroblasts and the activity of BAG3 as a factor able to induce the expression of \u03b1\u2010smooth muscle actin and the phosphorylation of AKT and focal adhesion kinase, that sustain CAF functions in tumor microenvironment. Furthermore, in agreement with these findings, <jats:italic>bag3<\/jats:italic> gene expression has been analyzed by high throughput RNA sequencing databases from patients\u2010derived xenografts. A strong correlation between <jats:italic>bag3<\/jats:italic> gene expression and patients' survival was found in several types of fibrotic tumors. The results obtained provide encouraging data that identify BAG3 as a promising therapeutic target to counteract fibrosis in tumors.<\/jats:p>","DOI":"10.1002\/jcb.30171","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T11:48:54Z","timestamp":1636199334000},"page":"91-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["BAG3 induces \u03b1\u2010SMA expression in human fibroblasts and its over\u2010expression correlates with poorer survival in fibrotic cancer patients"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4134-1437","authenticated-orcid":false,"given":"Margot","family":"De Marco","sequence":"first","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"},{"name":"R&amp;D Division BIOUNIVERSA s.r.l.  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Del Papa","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Scleroderma Unit G. Pini Hospital  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Reppucci","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"},{"name":"R&amp;D Division BIOUNIVERSA s.r.l.  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Falco","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"},{"name":"R&amp;D Division BIOUNIVERSA s.r.l.  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Iaccarino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Brongo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"De Caro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Capunzo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-359X","authenticated-orcid":false,"given":"Maria Caterina","family":"Turco","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"},{"name":"R&amp;D Division BIOUNIVERSA s.r.l.  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-0857","authenticated-orcid":false,"given":"Alessandra","family":"Rosati","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"},{"name":"R&amp;D Division BIOUNIVERSA s.r.l.  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-4483","authenticated-orcid":false,"given":"Liberato","family":"Marzullo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry Schola Medica Salernitana University of Salerno  Baronissi Salerno Italy"},{"name":"R&amp;D Division BIOUNIVERSA s.r.l.  Baronissi Salerno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.504290"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0134-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12492"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2019.02.006"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"1235","article-title":"Prognostic significance of peritumoral fibrosis after resection of pancreatic head cancer","volume":"19","author":"Chen P","year":"2020","journal-title":"Oncol Lett"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky984"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1059"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.08.049"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.07.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01446-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00431-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0509-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39553-z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-3245"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00160"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0233"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-14-0001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2455"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx416"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317424"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4123"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-05890-8"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0682-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8040"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.565306"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3041"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27681"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188356"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01295"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.07.016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9695"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24302"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz430"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0027"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/516518"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93554"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.08.004"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.42"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315201"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.30171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.30171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.30171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:48:51Z","timestamp":1692992931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.30171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,6]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jcb.30171"],"URL":"https:\/\/doi.org\/10.1002\/jcb.30171","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,6]]},"assertion":[{"value":"2021-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}