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The misregulation of lncRNAs interrupting normal biological processes has been implicated in tumor formation and metastasis, resulting in cancer. Apoptosis and cell cycle, two main biological phenomena, are highly conserved and intimately coupled mechanisms. Hence, some cell cycle regulators can influence\u00a0both programmed cell death and cell division. Apoptosis eliminates defective and unwanted cells, and the cell cycle enables cells to replicate themselves. The improper regulation of apoptosis and cell cycle contributes to numerous disorders such as neurodegenerative and autoimmune diseases, viral infection, anemia, and mainly cancer. Cellular senescence is a tumor\u2010suppressing response initiated by environmental and internal stress factors. This phenomenon has recently attained more attention due to its therapeutic implications in the field of senotherapy. In this review, the regulatory roles of lncRNAs on apoptosis, cell cycle, and senescence will be discussed. First, the role of lncRNAs in mitochondrial dynamics and apoptosis is addressed. Next, the interaction between lncRNAs and caspases, pro\/antiapoptotic proteins, and also EGFR\/PI3K\/PTEN\/AKT\/mTORC1 signaling pathway will be investigated. Furthermore, the effect of lncRNAs in the cell cycle is surveyed through interaction with cyclins, cdks, p21, and wnt\/\u03b2\u2010catenin\/c\u2010myc pathway. Finally, the function of essential lncRNAs in cellular senescence is mentioned.<\/jats:p>","DOI":"10.1002\/jcb.30221","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T08:14:24Z","timestamp":1643789664000},"page":"995-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The various regulatory functions of long noncoding RNAs in apoptosis, cell cycle, and cellular senescence"],"prefix":"10.1002","volume":"123","author":[{"given":"Mohammad","family":"Heydarnezhad Asl","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Natural Sciences University of Tabriz Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Pasban Khelejani","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Faculty of Basic Sciences University of Maragheh Maragheh 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