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Acromegaly is associated with somatic disfigurement and a wide range of systemic manifestations such as arthritis, neuropathy, carpal tunnel syndrome, reproductive disorders, metabolic disorders, and gastrointestinal complications. The influence of excess GH\u00a0on the cellular level could aid in understanding the root causes of acromegaly\u2010related health complications. Previously, we found that GH excess induces DNA damage to somatic cells and reduces the stem cells number and causes premature aging. In this study, an in\u2010depth analysis of the acromegaly RNAseq data revealed the disruption of important biological cellular processes. Gene set enrichment analysis, heatmap, and enrichment analysis of acromegaly RNAseq data revealed induction of endoplasmic reticulum (ER) stress markers in various organs. Interestingly, the induction of ER stress was even more apparent than in aged zebrafish. Splicing of box\u2010binding protein\u20101 (XBP1) mRNA is a hallmark of ER stress. Therefore, we quantified spliced XBP1 mRNA in different organs of our acromegaly model. Thus, our study emphasizes the importance of ER stress in GH oversecretion, which is important for understanding the health complications of acromegaly.<\/jats:p>","DOI":"10.1002\/jcb.30301","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T07:50:23Z","timestamp":1655970623000},"page":"1411-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Induction of endoplasmic reticulum stress markers in an acromegaly model"],"prefix":"10.1002","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-9425","authenticated-orcid":false,"given":"Abdalla","family":"Elbialy","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine and Public Health University of Wisconsin\u2013Madison Madison Wisconsin USA"},{"name":"Faculty of Veterinary Medicine Damanhour University Damanhour 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