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Recently, it has been shown that inappropriate regulation of hepatic mitophagy is linked to the pathogenesis of the above\u2010mentioned liver diseases. As mitophagy maintains cellular homeostasis by removing damaged and nonfunctional mitochondria from the cell, the proper function of the molecules involved are of utmost importance. Thereby, mitochondrial E3 ubiquitin ligases as well as several deubiquitinases (DUBs) appear to play a unique role for the degradation of mitochondrial proteins and for proper execution of the mitophagy process by either adding or removing ubiquitin chains from target proteins. Therefore, these enzymes could be considered as valuable liver disease biomarkers and also as novel targets for therapy. In this review, we focus on the role of different DUBs on mitophagy and their contribution to NAFLD, NASH, alcohol\u2010related liver disease, and especially HCC.<\/jats:p>","DOI":"10.1002\/jcb.30312","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T13:31:53Z","timestamp":1659619913000},"page":"1634-1646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Mitochondria, mitophagy, and the role of deubiquitinases as novel therapeutic targets in liver pathology"],"prefix":"10.1002","volume":"123","author":[{"given":"Elham","family":"Aryapour","sequence":"first","affiliation":[{"name":"Faculty of Biochemistry and Molecular Medicine, and Biocenter Oulu University of Oulu Oulu 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