{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:35:14Z","timestamp":1787668514210,"version":"build-2736575974"},"reference-count":107,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurofibromatosis Type 1 (NF1) is a frequent cancer predisposition syndrome. The common hallmark of patients with this multisystemic genetic disorder is the formation of peripheral nerve sheath tumors, which can be seen as either dermal, plexiform, and malignant forms. MicroRNA (miRNA) is an essential gene regulation factor and consists of 22\u201325 nucleotides. MiRNAs are identified to act as both tumor suppressors and oncogenes (oncomirs) in a wide variety of human cancers. They play multiple roles in molecular pathways responsible for tumor homing, progression, and invasion. Long noncoding RNA (lncRNA) also has a key role in cancer transcriptomics. Altered lncRNA expression levels have been found in various malignancies. This review aims to summarize the role of two noncoding RNA groups, miRNAs and lncRNAs, in NF1 establishment, development, and progression. We also highlight their potential for future clinical interventions and devising new diagnostic tools.<\/jats:p>","DOI":"10.1002\/jcb.30349","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T07:14:53Z","timestamp":1667891693000},"page":"17-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The role of miRNAs and lncRNAs in neurofibromatosis type 1"],"prefix":"10.1002","volume":"124","author":[{"given":"Teymoor","family":"Khosravi","sequence":"first","affiliation":[{"name":"Student Research Committee Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-5084","authenticated-orcid":false,"given":"Morteza","family":"Oladnabi","sequence":"additional","affiliation":[{"name":"Gorgan Congenital Malformations Research Center Golestan University of Medical Sciences Gorgan Iran"},{"name":"Ischemic Disorders Research Center Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01622-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35002607"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf476"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2741\/3727"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.12.001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579766"},{"issue":"2","key":"e_1_2_7_8_1","first-page":"104","article-title":"A neurofibromatosis type 1 family report with multiple cases in 3 consecutive generations","volume":"19","author":"Oladnabi M","year":"2017","journal-title":"J\u00a0Gorgan Uni\u00a0Med\u00a0Sci"},{"issue":"5","key":"e_1_2_7_9_1","first-page":"11311","article-title":"NF1 mutations analysis using whole exome sequencing technique in 11 unrelated Iranian families with neurofibromatosis type 1","volume":"8","author":"Foji S","year":"2020","journal-title":"Int J Pediatr"},{"issue":"1","key":"e_1_2_7_10_1","first-page":"15","article-title":"Study of the Demographic and Clinical profile in a neurocutaneous rare disease: a cross\u2010sectional study","volume":"31","author":"Jouybari L","year":"2020","journal-title":"Acta Neurol Taiwan"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112313052704"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-021-01170-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33045"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35535"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04399.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2012.04377.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1868"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105023241807"},{"issue":"7","key":"e_1_2_7_20_1","first-page":"799","article-title":"Lisch and the importance of his nodules","volume":"63","author":"Maharaj A","year":"2014","journal-title":"West Indian Med J"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb48061.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-473"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1382021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22098"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091960"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-009-0045-z"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2006.2.3.213"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12115"},{"issue":"1","key":"e_1_2_7_29_1","first-page":"137","article-title":"Vascular endothelial growth factor, basic fibroblast growth factor and epithelial growth factor receptor in peripheral nerve sheath tumors of neurofibromatosis type 1","volume":"35","author":"Friedrich RE","year":"2015","journal-title":"Anticancer Res"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3838"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3947"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R900012200"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.24.110707.175327"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03049"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1262504"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178705"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20140142"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.017"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1733"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2936"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05983"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09092"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11142"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4037"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp212"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","unstructured":"PaschouM DoxakisE. Neurofibromin 1 is a miRNA target in neurons.\u00a02012.","DOI":"10.1371\/journal.pone.0046773"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-7364-6-23"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.09.038"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4914"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2020.01.001"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519850739"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08759-0"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.1.35"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10206"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10299"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20289"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21271"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050746"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.014761"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320590427"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1086\/374821"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01581-9"},{"issue":"8","key":"e_1_2_7_63_1","first-page":"1236","article-title":"The oncogenic role of miR\u2010155 in breast cancer. Cancer epidemiology and Prevention","volume":"21","author":"Mattiske S","year":"2012","journal-title":"Biomarkers"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36321-3"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-448"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.31361"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6297-6"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-020-01779-2"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5839-2"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317691657"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0211-4"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.05.042"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1231"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2876"},{"issue":"4","key":"e_1_2_7_75_1","first-page":"1623","article-title":"miR\u2010135 regulated breast cancer proliferation and epithelial\u2010mesenchymal transition acts by the Wnt\/\u03b2\u2010catenin signaling pathway","volume":"43","author":"Jiang D","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.679348"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246162"},{"issue":"6","key":"e_1_2_7_78_1","first-page":"8744","article-title":"miR\u2011137 suppresses proliferation, migration and invasion of colon cancer cell lines by targeting TCF4","volume":"15","author":"Bi WP","year":"2018","journal-title":"Oncol Lett"},{"issue":"5","key":"e_1_2_7_79_1","first-page":"7460","article-title":"[Corrigendum] MicroRNA\u2010137 has a suppressive role in liver cancer via targeting EZH2","volume":"17","author":"Cui S","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0092-x"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22678"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22107"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870100405"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2633"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10080563"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01616.x"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06174"},{"issue":"9","key":"e_1_2_7_88_1","first-page":"1674","article-title":"The fundamental role of miR\u201010b in metastatic cancer","volume":"8","author":"Sheedy P","year":"2018","journal-title":"Am J Cancer Res"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-5-2"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14110"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.518"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-125856"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00021-X"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos124"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-012-1223-1"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.10.002"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0531-x"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-021-02363-3"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-017-1766-y"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2010.00079"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2166"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053765"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36531"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr416"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-13-98"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10110892"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.62573"},{"issue":"18","key":"e_1_2_7_108_1","first-page":"5946","article-title":"LncRNA H19 serves as a ceRNA and participates in non\u2010small cell lung cancer development by regulating microRNA\u2010107","volume":"22","author":"Qian B","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.30349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcb.30349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.30349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T15:45:23Z","timestamp":1692459923000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.30349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,19]]},"references-count":107,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jcb.30349"],"URL":"https:\/\/doi.org\/10.1002\/jcb.30349","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,19]]},"assertion":[{"value":"2022-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}