{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:00:59Z","timestamp":1765486859722,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous pathogens affecting human is present in the <jats:italic>flavivirus<\/jats:italic> family namely west nile, dengue, yellow fever, and zika which involves in development of global burden and distressing the environment economically. Till date, no approved drugs are available for targeting these viruses. The threat which urged the identification of small molecules for the inhibition of these viruses is the spreading of serious viral diseases. The recent outbreak of zika and dengue infections postured a solemn risk to worldwide public well\u2010being. RNA\u2010dependent RNA polymerase (RdRp) is the supreme adaptable enzymes of all the RNA viruses which is responsible for the replication and transcription of genome among the structural and nonstructural proteins of <jats:italic>flaviviruses<\/jats:italic>. It is understood that the RdRp of the <jats:italic>flaviviruses<\/jats:italic> are similar stating that the japanese encephalitis and west nile shares 70% identity with zika whereas the dengue serotype 2 and 3 shares the identity of 76% and 81%, respectively. In this study, we investigated the binding site of four flaviviral RdRp and provided insights into various interaction of the molecules using the computational approach. Our study helps in recognizing the potent compounds that could inhibit the viral protein as a common inhibitor. Additionally, with the conformational stability analysis, we proposed the possible mechanism of inhibition of the identified common small molecule toward\u00a0RdRp of <jats:italic>flavivirus<\/jats:italic>. Finally, this study could be an initiative for the identification of common inhibitors and can be explored further for understanding the mechanism of action through in vitro studies for the study on efficacy.<\/jats:p>","DOI":"10.1002\/jcb.30352","type":"journal-article","created":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T18:20:37Z","timestamp":1670782837000},"page":"127-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Drug repurposing toward\u00a0the inhibition of RNA\u2010dependent RNA polymerase of various <i>flaviviruses<\/i> through computational study"],"prefix":"10.1002","volume":"124","author":[{"given":"Aarthy","family":"Murali","sequence":"first","affiliation":[{"name":"Computer Aided Drug Designing and Molecular Modeling Lab, Department of Bioinformatics Alagappa University Karaikudi Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Computer Aided Drug Designing and Molecular Modeling Lab, Department of Bioinformatics Alagappa University Karaikudi Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasan","family":"Akshaya","sequence":"additional","affiliation":[{"name":"Bishop Heber College Trichy Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-6437","authenticated-orcid":false,"given":"Sanjeev K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Computer Aided Drug Designing and Molecular Modeling Lab, Department of Bioinformatics Alagappa University Karaikudi Tamil Nadu India"},{"name":"Department of Data Sciences, Centre of Biomedical Research Sanjay Gandhi Post Institute of Medical Sciences Campus Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.04.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60238-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1144"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-016-0132-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600064"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02165"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12385"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00048-20"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100750"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.12.7143-7149.2003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8004-8013.2005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.05.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2419"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.11.026"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.07.001"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2015.1116411"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666181025100736"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai9309"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.06.105"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2017.1384400"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.2216"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b01002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666181115092001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666181129144107"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2017.1397058"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.03.026"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65446-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28181"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c01619"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2019.1597767"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.08.052"},{"key":"e_1_2_9_33_1","unstructured":"Prime. 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