{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:29:40Z","timestamp":1787239780084,"version":"build-2736575974"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2016\/000817\/LS"],"award-info":[{"award-number":["ECR\/2016\/000817\/LS"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR26841\/MED\/122\/121\/2017"],"award-info":[{"award-number":["BT\/PR26841\/MED\/122\/121\/2017"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Metacestode, the larva of\n                    <jats:italic>Taenia solium<\/jats:italic>\n                    , is the causative agent for neurocysticercosis (NCC), which causes epilepsy. The unavailability of a vaccine against human NCC is a major cause for its widespread prevalence across the globe. Therefore, the development of a reliable vaccine against NCC is the need of the hour. Employing a combination of proteomics and immunoinformatics, we endeavored to formulate a vaccine candidate. The immune reactive cyst fluid antigens\u00a0of\n                    <jats:italic>T. solium<\/jats:italic>\n                    were identified by immune\u2010blotting two\u2010dimensional gels with NCC patient's sera, followed by Matrix\u2010assisted laser desorption\u2010ionization\u00a0analysis. We performed a detailed proteomic study of these immune reactive proteins by utilizing immune\u2010informatics tools, identified the nontoxic, nonallergic, B\u2010cell epitopes, and collected epitopes with the least sequence homology with human and other\n                    <jats:italic>Taenia<\/jats:italic>\n                    species. These epitopes were joined through linkers to construct a multiepitope vaccine. Different physiochemical parameters such as molecular weight (23.82\u2009kDa), instability (39.91), and aliphatic index (49.61) were calculated to ensure the stability of the linked peptides vaccine. The vaccine demonstrated stable interactions with different immune receptors like Toll\u2010like receptor 4\u00a0and IgG confirming that it will effectively stimulate the host immune response. We anticipate that our designed B\u2010cell linear epitope\u2010based vaccine will show promising results in in vitro and in vivo assays. This study provides a platform that would be useful to develop other suitable vaccine candidates to prevent helminthic neglected tropical diseases in near future.\n                  <\/jats:p>","DOI":"10.1002\/jcb.30467","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:35:13Z","timestamp":1694493313000},"page":"1587-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Recognition of immune reactive proteins as a potential multiepitope vaccine candidate of\n                    <i>Taenia solium<\/i>\n                    cysticerci through proteomic approach"],"prefix":"10.1002","volume":"124","author":[{"given":"Rimanpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"School of Biosciences and Bioengineering Indian Institute of Technology Mandi Mandi Himachal Pradesh 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