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However, the repercussions of this viral pandemic may remain with us for a longer period of time, as it has remodeled the lives of humankind in many ways, including social and economic. Of course, its most important repercussions remain on the human health level. Long\u2010coronavirus disease (COVID) or post\u2010COVID is a state for which we do not have a concrete definition, a specific international classification of diseases Code, clear diagnostic tools, or well\u2010known effective cures as of yet. In this second article from the Intrinsic Factors behind long\u2010COVID Series, we try to link long\u2010COVID symptoms with their causes, starting from the nervous system. Extracellular vesicles (ECVs) play very complex and ramified roles in the bodies of both healthy and not\u2010healthy individuals. ECVs may facilitate the entry of many bioactive molecules and pathogens into the tissues and cells of the nervous system across the blood\u2013brain barrier. Based on the size, quantity, and quality of their cargo, ECVs are directly proportional to the pathological condition and its severity through intertwined mechanisms that evoke inflammatory immune responses typically accompanied by pathological symptoms over variable time periods according to the type of these symptoms.<\/jats:p>","DOI":"10.1002\/jcb.30486","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T05:12:57Z","timestamp":1696655577000},"page":"1466-1485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intrinsic factors behind long\u2010COVID: II. SARS\u2010CoV\u20102, extracellular vesicles, and neurological disorders"],"prefix":"10.1002","volume":"124","author":[{"given":"Yousra A.","family":"El\u2010Maradny","sequence":"first","affiliation":[{"name":"Protein Research Department Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA\u2010City) New Borg EL\u2010Arab Egypt"},{"name":"Microbiology and Immunology, Faculty of Pharmacy Arab Academy for Science, Technology and Maritime Transport (AASTMT) El\u2010Alamein Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Rubio\u2010Casillas","sequence":"additional","affiliation":[{"name":"Biology Laboratory, Autl\u00e1n Regional Preparatory School University of Guadalajara Autl\u00e1n Jalisco Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem I.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology, Faculty of Pharmacy Arab Academy for Science, Technology and Maritime Transport (AASTMT) El\u2010Alamein Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4037-5857","authenticated-orcid":false,"given":"Vladimir N.","family":"Uversky","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute Morsani College of Medicine, University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elrashdy M.","family":"Redwan","sequence":"additional","affiliation":[{"name":"Biological Science Department Faculty of Science, King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113499"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2020.173"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012578"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00860"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9050497"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.18931"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101961"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.0750"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0398-3"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26570"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117090"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd2985"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091947"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.571996"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2020.104422"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1790426"},{"issue":"5","key":"e_1_2_10_19_1","first-page":"656","article-title":"Intrinsic 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