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Currently, it has become a hot spot for research. With the discovery of its powerful regulatory functions and roles, the molecular mechanisms and future value of circRNA in participating in and regulating biological and pathological processes are becoming increasingly apparent. Among them is the increasing prevalence of cardiovascular diseases (CVDs). Many studies have elucidated that circRNA plays a crucial role in the development and progression of CVDs. Therefore, circRNA shows its advantages and brilliant expectations in the field of CVDs. In this review, we describe the biogenesis, bioinformatics detection and function of circRNA and discuss the role of circRNA and its effects on CVDs, including atherosclerosis, myocardial infarction, cardiac hypertrophy and heart failure, myocardial fibrosis, cardiac senescence, pulmonary hypertension, and diabetic cardiomyopathy by different mechanisms. That shows circRNA advantages and brilliant expectations in the field of CVDs.<\/jats:p>","DOI":"10.1002\/jcb.30512","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T01:45:23Z","timestamp":1702604723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Circular RNA: A new expectation for cardiovascular diseases"],"prefix":"10.1002","volume":"125","author":[{"given":"Qiao","family":"Xie","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology, Hengyang Medical College University of South China Hengyang Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5893-5317","authenticated-orcid":false,"given":"Yun","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Biology, Hengyang Medical College University of South China Hengyang Hunan 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