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A multitude of long\u2010lasting symptoms have been reported several weeks after the primary acute SARS\u2010CoV\u20102 infection that resemble several other viral infections. Thousands of research articles have described various post\u2010COVID\u201019 conditions. Yet, the evidence around these ongoing health problems, the reasons behind them, and their molecular underpinnings are scarce. These persistent symptoms are also known as long COVID\u201019. The persistence of SARS\u2010CoV\u20102 and\/or its components in host tissues can lead to long COVID. For example, the presence of viral nucleocapsid protein and RNA was detected in the skin, appendix, and breast tissues of some long COVID patients. The persistence of viral RNA was reported in multiple anatomic sites, including non\u2010respiratory tissues such as the adrenal gland, ocular tissue, small intestine, lymph nodes, myocardium, and sciatic nerve. Distinctive viral spike sequence variants were also found in non\u2010respiratory tissues. Interestingly, prolonged detection of viral subgenomic RNA was observed across all tissues, sometimes in multiple tissues of the same patient, which likely reflects recent but defective viral replication. Moreover, the persistence of SARS\u2010CoV\u20102 RNA was noticed throughout the brain at autopsy, as late as 230 days following symptom onset among unvaccinated patients who died of severe infection. Here, we review the persistence of SARS\u2010CoV\u20102 and its components as an intrinsic factor behind long COVID. We also highlight the immunological consequences of this viral persistence.<\/jats:p>","DOI":"10.1002\/jcb.30514","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T07:50:19Z","timestamp":1702626619000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intrinsic factors behind long COVID: III. Persistence of SARS\u2010CoV\u20102 and its components"],"prefix":"10.1002","volume":"125","author":[{"given":"Nawal Abd","family":"El\u2010Baky","sequence":"first","affiliation":[{"name":"Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI) City of Scientific Research and Technological Applications (SRTA\u2010City) New Borg El\u2010Arab City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amro A.","family":"Amara","sequence":"additional","affiliation":[{"name":"Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI) City of Scientific Research and Technological Applications (SRTA\u2010City) New Borg El\u2010Arab City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4037-5857","authenticated-orcid":false,"given":"Vladimir N.","family":"Uversky","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, USF 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