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Currently, no specific and compelling drug treatment plan exists. Mesenchymal stem cells (MSCs) have shown promising results in preclinical and clinical studies as a potential treatment for ALI and other lung\u2010related conditions due to their immunomodulatory properties and ability to regenerate various cell types. The present study focuses on analyzing the role of umbilical cord MSC (UC\u2010MSC))\u2010derived exosomes in reducing lipopolysaccharide\u2010induced ALI and investigating the mechanism involved. The study demonstrates that UC\u2010MSC\u2010derived exosomes effectively improved the metabolic function of alveolar macrophages and promoted their shift to an anti\u2010inflammatory phenotype, leading to a reduction in ALI. The findings also suggest that creating three\u2010dimensional microspheres from the MSCs first can enhance the effectiveness of the exosomes. Further research is needed to fully understand the mechanism of action and optimize the therapeutic potential of MSCs and their secretome in ALI and other lung\u2010related conditions.<\/jats:p>","DOI":"10.1002\/jcb.30519","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T11:08:20Z","timestamp":1705316900000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Umbilical cord MSC\u2010derived exosomes improve alveolar macrophage function and reduce LPS\u2010induced acute lung injury"],"prefix":"10.1002","volume":"125","author":[{"given":"Enhai","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Huzhou Central Hospital, Affiliated Huzhou Hospital Zhejiang University School of Medicine Huzhou Zhejiang 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