{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:44:48Z","timestamp":1772793888935,"version":"3.50.1"},"reference-count":272,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When the SARS\u2010CoV\u20102\u00a0virus infects humans, it leads to a condition called COVID\u201019\u00a0that has a wide spectrum of clinical manifestations, from no symptoms to acute respiratory distress syndrome. The virus initiates damage by attaching to the ACE\u20102\u00a0protein on the surface of endothelial cells that line the blood vessels and using these cells as hosts for replication. Reactive oxygen species levels are increased during viral replication, which leads to oxidative stress. About three\u2010fifths\u00a0(~60%) of the people who get infected with the virus eradicate it from their body after 28 days and recover their normal activity. However, a large fraction (~40%) of the people who are infected with the virus suffer from various symptoms (anosmia and\/or ageusia, fatigue, cough, myalgia, cognitive impairment, insomnia, dyspnea, and tachycardia) beyond 12 weeks and are diagnosed with a syndrome called long COVID. Long\u2010term clinical studies in a group of people who contracted SARS\u2010CoV\u20102\u00a0have been contrasted with a noninfected matched group of people. A subset of infected people can be distinguished by a set of cytokine markers to have persistent, low\u2010grade inflammation and often self\u2010report two or more bothersome symptoms. No medication can alleviate their symptoms efficiently. Coronavirus nucleocapsid proteins have been investigated extensively as potential drug targets due to their key roles in virus replication, among which is their ability to bind their respective genomic RNAs for incorporation into emerging virions. This review highlights basic studies of the nucleocapsid protein and its ability to undergo liquid\u2013liquid phase separation. We hypothesize that this ability of the nucleocapsid protein for phase separation may contribute to long COVID. This hypothesis unlocks new investigation angles and could potentially open novel avenues for a better understanding of long COVID and treating this condition.<\/jats:p>","DOI":"10.1002\/jcb.30530","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T13:44:34Z","timestamp":1707831874000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intrinsic factors behind long COVID: IV. Hypothetical roles of the SARS\u2010CoV\u20102 nucleocapsid protein and its liquid\u2013liquid phase separation"],"prefix":"10.1002","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7107-5768","authenticated-orcid":false,"given":"Ahmed","family":"Eltayeb","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-3570","authenticated-orcid":false,"given":"Faisal","family":"Al\u2010Sarraj","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-5496","authenticated-orcid":false,"given":"Raed","family":"Albiheyri","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Centre of Excellence in Bionanoscience Research King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Immunology Unit, King Fahad Medical Research Centre King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab H.","family":"Mattar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isam M.","family":"Abu Zeid","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamer A.","family":"Bouback","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atif","family":"Bamagoos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4037-5857","authenticated-orcid":false,"given":"Vladimir N.","family":"Uversky","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine University of South Florida Tampa Florida USA"},{"name":"Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences Moscow Region Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Rubio\u2010Casillas","sequence":"additional","affiliation":[{"name":"Autlan Regional Hospital Health Secretariat Autlan Jalisco Mexico"},{"name":"Biology Laboratory, Autlan Regional Preparatory School University of Guadalajara Autlan Jalisco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-0075","authenticated-orcid":false,"given":"Elrashdy M.","family":"Redwan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Centre of Excellence in Bionanoscience Research King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.691"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa706"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abh3826"},{"key":"e_1_2_16_5_1","unstructured":"NICE.COVID\u201019 rapid guideline: managing the long\u2010term effects of COVID\u201019.2020."},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3489"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01202-8"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0916-2"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01402-w"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00384-2021"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01113-x"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-021-00423-z"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01433-3"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.15959"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01283-z"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa623"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.07.001"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109633"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14726"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-021-01693-6"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5801"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00965-3"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00850-3"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04276-4"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119102"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2019.03.005"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2694"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.07.001"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1262"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200828"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2012.12.008"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2019.00010"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201700193"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11060990"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-062920-063704"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9120842"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11193040"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015418"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/plcell\/koab240"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115821"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.035"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb8032"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01076-x"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102678"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.08.132"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.118984"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2022.01449"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00408-2"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-020-00788-2"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.08.007"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-00578-6"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0264-6"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2021.103179"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202004062"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat1022"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00774-x"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.047"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/112_2020_37"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz4427"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032151"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12977-023-00619-6"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13030366"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-00240-3"},{"key":"e_1_2_16_66_1","doi-asserted-by":"crossref","unstructured":"IsermanC RodenC BoernekeM et al. Specific viral RNA drives the SARS CoV\u20102 nucleocapsid to phase separate.bioRxiv. 2020.doi:10.1101\/2020.06.11.147199","DOI":"10.1101\/2020.06.11.147199"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.11.041"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20768-y"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020106478"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21953-3"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.01.018"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19843-1"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.015"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.004"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0050059"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-071819-113553"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-823967-4.00002-6"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00336"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001351"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.11.025"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.09.018"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-021-00306-w"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2021.01.013"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14229"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00575-7"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102523"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00127-8"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00710-0"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-021-00832-z"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22297-8"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.58"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00046-9"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.139"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11250"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.001"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03416-6"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.032"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01287-10"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0167"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa453"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6027"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12121433"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.52"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.012"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.020"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183434.111"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01380-20"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.10.004"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1358-4"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.03.037"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-021-00839-6"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.01.024"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00659-0"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1010911"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abg8744"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.07.004"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00841-18"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab689"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.05.002"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109217"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01269-0"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.2.958-967.2004"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.05.006"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780210906"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008689"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.824967"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13061025"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2017.03.001"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202211015"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010652"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.985622"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1162211"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009926"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab126"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-020-1702-x"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-021-00129-0"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00400-7"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239045"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003273"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03901-9"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2016.10.009"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.40.100186.001111"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00036-2"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03207-w"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00550-2"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603144103"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.07.023"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.004"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04082-x"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1027"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.09.023"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c00901"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/life7020028"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013325"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.007895"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.TM118.001192"},{"issue":"4","key":"e_1_2_16_158_1","first-page":"175","article-title":"Regulation of stress granules in virus systems","volume":"20","author":"White JP","year":"2012","journal-title":"TIM"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.63"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.11.020"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.07.004"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.12.022"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202004120"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.027"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00331-3"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00572-5"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-021-00275-0"},{"key":"e_1_2_16_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1389"},{"key":"e_1_2_16_169_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009494"},{"key":"e_1_2_16_170_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200512082"},{"key":"e_1_2_16_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12669"},{"key":"e_1_2_16_172_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806372200"},{"key":"e_1_2_16_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.06.033"},{"key":"e_1_2_16_174_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.622057"},{"key":"e_1_2_16_175_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.220244"},{"key":"e_1_2_16_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19104-1"},{"key":"e_1_2_16_177_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112742"},{"key":"e_1_2_16_178_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.248310"},{"key":"e_1_2_16_179_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvy062"},{"key":"e_1_2_16_180_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.103172al"},{"key":"e_1_2_16_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.02.025"},{"key":"e_1_2_16_182_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.647884"},{"key":"e_1_2_16_183_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.078858.121"},{"key":"e_1_2_16_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.015"},{"key":"e_1_2_16_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703348104"},{"key":"e_1_2_16_186_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02186-12"},{"key":"e_1_2_16_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.02.025"},{"key":"e_1_2_16_188_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.06549-11"},{"key":"e_1_2_16_189_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009072"},{"key":"e_1_2_16_190_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00474-17"},{"key":"e_1_2_16_191_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-023-02061-8"},{"key":"e_1_2_16_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25015-6"},{"key":"e_1_2_16_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0256-z"},{"key":"e_1_2_16_194_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.799558"},{"key":"e_1_2_16_195_1","volume-title":"Immunity, ADP Ribosylation and Vesicular Transport (September 24, 2020). iSCIENCE\u2013September","author":"Nallur G","year":"2020"},{"key":"e_1_2_16_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03491-w"},{"key":"e_1_2_16_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2021.06.002"},{"key":"e_1_2_16_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111968"},{"key":"e_1_2_16_199_1","doi-asserted-by":"publisher","DOI":"10.6064\/2012\/857516"},{"key":"e_1_2_16_200_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03154"},{"key":"e_1_2_16_201_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15010156"},{"key":"e_1_2_16_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.09.013"},{"key":"e_1_2_16_203_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC05266G"},{"key":"e_1_2_16_204_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2022.5099"},{"key":"e_1_2_16_205_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13086"},{"key":"e_1_2_16_206_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756286420932036"},{"key":"e_1_2_16_207_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042718-041417"},{"key":"e_1_2_16_208_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2020.146"},{"key":"e_1_2_16_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25915"},{"key":"e_1_2_16_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.03.031"},{"key":"e_1_2_16_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.03.010"},{"key":"e_1_2_16_212_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00757-x"},{"key":"e_1_2_16_213_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01476-14"},{"key":"e_1_2_16_214_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88720"},{"key":"e_1_2_16_215_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069123"},{"key":"e_1_2_16_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.11.012"},{"key":"e_1_2_16_217_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05068-7"},{"key":"e_1_2_16_218_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00814-w"},{"key":"e_1_2_16_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.008"},{"key":"e_1_2_16_220_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15372"},{"key":"e_1_2_16_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.05.010"},{"key":"e_1_2_16_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01214-4"},{"key":"e_1_2_16_223_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abg7113"},{"key":"e_1_2_16_224_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.784145"},{"key":"e_1_2_16_225_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.698169"},{"key":"e_1_2_16_226_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.04.037"},{"key":"e_1_2_16_227_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06716-y"},{"key":"e_1_2_16_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100287"},{"key":"e_1_2_16_229_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2815"},{"key":"e_1_2_16_230_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07153-4"},{"key":"e_1_2_16_231_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021865"},{"key":"e_1_2_16_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103355"},{"key":"e_1_2_16_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00931-1"},{"key":"e_1_2_16_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.10.021"},{"key":"e_1_2_16_235_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23621-y"},{"key":"e_1_2_16_236_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176204"},{"key":"e_1_2_16_237_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.97"},{"key":"e_1_2_16_238_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155386"},{"key":"e_1_2_16_239_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124223"},{"key":"e_1_2_16_240_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156995"},{"key":"e_1_2_16_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.161"},{"key":"e_1_2_16_242_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0420"},{"key":"e_1_2_16_243_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124459"},{"key":"e_1_2_16_244_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_16_245_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203276"},{"key":"e_1_2_16_246_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11729"},{"key":"e_1_2_16_247_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8360"},{"key":"e_1_2_16_248_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25829"},{"key":"e_1_2_16_249_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI161167"},{"key":"e_1_2_16_250_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_16_251_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06062-x"},{"key":"e_1_2_16_252_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020301"},{"key":"e_1_2_16_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.05.004"},{"key":"e_1_2_16_254_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"e_1_2_16_255_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2022-002241"},{"key":"e_1_2_16_256_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2022-070230","article-title":"Development and validation of the symptom burden questionnaire for long covid (SBQ\u2010LC): Rasch analysis","volume":"377","author":"Hughes SE","year":"2022","journal-title":"BMJ"},{"key":"e_1_2_16_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.357"},{"key":"e_1_2_16_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2022.02.012"},{"key":"e_1_2_16_259_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.220069"},{"key":"e_1_2_16_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.07.004"},{"issue":"3","key":"e_1_2_16_261_1","first-page":"307","article-title":"Therapeutics\u2010how to treat phase separation\u2010associated diseases","volume":"4","author":"Wheeler RJ","year":"2020","journal-title":"Emerg Top Life Sci"},{"key":"e_1_2_16_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2013.01.003"},{"key":"e_1_2_16_263_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215501"},{"key":"e_1_2_16_264_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00098"},{"key":"e_1_2_16_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.09.014"},{"key":"e_1_2_16_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.09.017"},{"key":"e_1_2_16_267_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051023"},{"key":"e_1_2_16_268_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901897R"},{"key":"e_1_2_16_269_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c05750"},{"key":"e_1_2_16_270_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1017542"},{"key":"e_1_2_16_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2022.07.012"},{"key":"e_1_2_16_272_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.048983"},{"key":"e_1_2_16_273_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001425"}],"container-title":["Journal of Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcb.30530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T16:52:05Z","timestamp":1710175925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcb.30530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,13]]},"references-count":272,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jcb.30530"],"URL":"https:\/\/doi.org\/10.1002\/jcb.30530","archive":["Portico"],"relation":{},"ISSN":["0730-2312","1097-4644"],"issn-type":[{"value":"0730-2312","type":"print"},{"value":"1097-4644","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,13]]},"assertion":[{"value":"2023-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30530"}}