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In a healthy condition, cytokines act as potent mediators of immune responses. They orchestrate the activities of immune cells, coordinating their proliferation, differentiation, and migration. This intricate role of cytokine signalling enables the body to effectively combat infections, repair damaged tissues, and regulate inflammation. However, the delicate equilibrium of cytokine production is susceptible to disruption. Excessive or abnormal cytokine levels can lead to a cascade of pathological conditions, including autoimmune diseases, chronic inflammation, infections, allergies, and even cancer. Interestingly, from the bunch of cytokines, few cytokines play an essential role in maintaining the balance between normal physiological status and diseases. In this review, we have appraised key cytokines' potential role and feedback loops in augmenting the imbalances in the body's biological functions, presenting a critical link between inflammation and disease pathology. Moreover, we have also highlighted the significance of cytokines and their molecular interplay, particularly in the recent viral pandemic COVID\u201019 disease. Hence, understandings regarding the interplay between viral infection and cytokine responses are essential and fascinating for developing effective therapeutic strategies.<\/jats:p>","DOI":"10.1002\/jcb.30680","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:20:29Z","timestamp":1734067229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Snapshot of Cytokine Dynamics: A Fine Balance Between Health and Disease"],"prefix":"10.1002","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4433-0354","authenticated-orcid":false,"given":"Sumit","family":"Mallick","sequence":"first","affiliation":[{"name":"Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre Yenepoya (Deemed to be University) University Road, Deralakatte Mangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim 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