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In the regulation of Wnt\/\u03b2\u2010catenin, Forkhead box k1(<jats:italic>FOXK1<\/jats:italic>), Frizzled class receptor 3 (<jats:italic>FZD3<\/jats:italic>), and <jats:italic>Wnt5b<\/jats:italic> can be targeted and inhibited by three tRFs: tRF3008A targets <jats:italic>FOXK1<\/jats:italic> to inhibit colorectal cancer (CRC), 5\u2032\u2010tiRNAVal targets <jats:italic>FZD3<\/jats:italic> to inhibit breast cancer (BrC), and tRF\u201022\u20108BWS7K092 targets <jats:italic>Wnt5b<\/jats:italic> to induce ferroptosis in lung cells. Additionally, tRF\u201024\u2010V29K9UV3IU can inhibit the levels of FZD3, Van Gogh\u2010like protein 1 (VANGL1), and cyclin D2 (CCND2) through an unexplained mechanism and play a role in inhibiting gastric cancer (GC). Clinical data has shown that the expression levels of certain tRFs are associated with the prognosis and pathological features of CRC and BrC patients. Low expression of tRF3008A is associated with poor prognosis and adverse pathological features in CRC patients, while high expression of tiRNA\u2010Phe\u2010GAA\u2010003 and low expression of 5\u2032\u2010tiRNAVal are associated with poor prognosis and adverse pathological features in BrC patients. KEGG analysis has also shown that a variety of tRFs are involved in regulating the Wnt pathway and have been shown to play a role in a variety of diseases. For example, high expression of tRF\u2010Gly\u2010CCC\u2010039 is associated with poor healing of diabetic foot, low expression of tsRNA\u201010277 is associated with high incidence of steroid\u2010induced osteonecrosis of the femoral head (SONFH), high expression of tRF\u201022\u20108BWS7K092 is correlated with the severity of acute lung injury (ALI), and low expression of tsRNA\u201021109 is associated with the severity of systemic lupus erythematosus (SLE), and high expression of tRF\u201036\u2010F900BY4D\u201084KRIME and tRF\u201023\u201087R8WP9IY, as well as low expression of tRF\u201040\u201086J8WPMN1E8Y7Z2R, were associated with high incidence of varicose vein (VV), and high expression of ts\u201034, was associated with high mortality of BrC. This article summarizes the biological function and mechanism of tRFs related to the Wnt pathway in cancer and other diseases, providing a new direction for subsequent translational medical research.<\/jats:p>","DOI":"10.1002\/jcb.30702","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T13:22:56Z","timestamp":1737465776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Recent Insights Into Wnt\u2010Related tRNA\u2010Derived Fragments (tRFs) in Human Diseases"],"prefix":"10.1002","volume":"126","author":[{"given":"Jinze","family":"Shen","sequence":"first","affiliation":[{"name":"Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine Hangzhou City University Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qurui","family":"Wang","sequence":"additional","affiliation":[{"name":"Key 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