{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:05:43Z","timestamp":1785326743913,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Notoginsenoside R1 (NR1), an active component of\n                    <jats:italic>Panax notoginseng<\/jats:italic>\n                    , may exert anti\u2010atherosclerotic effects by modulating macrophage M1\/M2 polarization. This study aimed to investigate the specific mechanism of NR1 against atherosclerosis based on the JAK1\/STAT3 pathway. M1 and M2 macrophage models, as well as an ox\u2010LDL\u2010induced macrophage model, were established. These models were treated with varying concentrations of NR1. Our results demonstrated that NR1 effectively suppressed LPS\/IFN\u2010\u03b3 or ox\u2010LDL\u2010induced polarization of macrophages toward the pro\u2010inflammatory M1 phenotype and promoted their transition to the anti\u2010inflammatory M2 phenotype. Concurrently, NR1 significantly inhibited the phagocytosis of ox\u2010LDL by macrophages in the atherosclerosis model, reduced lipid accumulation, and improved mitochondrial function. Mechanistically, the regulatory effects of NR1 on macrophage polarization and function primarily depended on the inhibition of the JAK1\/STAT3 signaling pathway. In conclusion, this study suggests that NR1 targets the JAK1\/STAT3 pathway to balance macrophage M1\/M2 polarization, thereby suppressing inflammatory responses, and ultimately alleviating atherosclerosis.\n                  <\/jats:p>","DOI":"10.1002\/jcb.70112","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:21:21Z","timestamp":1785324081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Notoginsenoside R1 Alleviates Macrophage Inflammatory Responses via Modulating the JAK1\/STAT3 Pathway"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1203-5468","authenticated-orcid":false,"given":"Chengjie","family":"Wu","sequence":"first","affiliation":[{"name":"Shaoxing People's Hospital Shaoxing China"},{"name":"The First Hospital of Shaoxing University Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Hou","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medical Hospital of Zhuji Zhuji China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaoxing People's Hospital Shaoxing China"},{"name":"The First Hospital of Shaoxing University Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Feng","sequence":"additional","affiliation":[{"name":"Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengneng","family":"Ji","sequence":"additional","affiliation":[{"name":"Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[{"name":"Shaoxing People's Hospital Shaoxing China"},{"name":"The First Hospital of Shaoxing University Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"issue":"36","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1093\/eurheartj\/ehae471","article-title":"Atherosclerosis Quantification and Cardiovascular Risk: The Ischemia Trial","volume":"45","author":"Nurmohamed N. 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