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However, its function often exhibits contradictory effects: In renal fibrosis, ALKBH5 has been reported to both promote and suppress fibrogenesis, whereas in renal cell carcinoma most studies support an oncogenic role, but some clinical observations link ALKBH5 downregulation to poor prognosis. These contradictions may stem from differences in cell types, disease stages, and microenvironments. This manuscript systematically reviews the complex function of ALKBH5 in kidney diseases and its underlying mechanisms, explores its potential as a therapeutic target, evaluates its therapeutic potential, and highlights the need for cell\u2010 and pathology\u2010specific strategies to enable precise intervention. Future research should focus on its cell and pathological background specificity to achieve precise intervention.<\/jats:p>","DOI":"10.1002\/jcb.70114","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T17:25:57Z","timestamp":1785691557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Role of ALKBH5 in Kidney Injury: Insights Into Mechanisms and Therapeutic Potential"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1733-3926","authenticated-orcid":false,"given":"YiFeng","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Nephrology Zhongnan Hospital of Wuhan University Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9016-5268","authenticated-orcid":false,"given":"Danqin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department 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