{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:56:27Z","timestamp":1790574987224,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The Warburg effect\u2010induced lactate production in T\u2010cell acute lymphoblastic leukemia (T\u2010ALL) cell proliferation is well established, however, the role of lactate\u2010mediated protein lactylation in this process remains poorly understood. In this study, we demonstrated that inhibiting lactate levels through the lactate dehydrogenase A (LDHA) inhibitor significantly reduced both cell proliferation and protein lactylation levels in T\u2010ALL cells. Lactate deficiency led to a marked decrease in protein lactylation, accompanied by impaired cell proliferation. Meanwhile, lactate deficiency also induced the S\u2011phase cell cycle arrest and reduced DNA synthesis, which collectively impaired cell proliferation. Mechanistically, we observed that the decreased expression of lactylation in histone H3 at lysine 18 (H3K18lac) reduced the enrichment of this mark on the promoter region of neurotrophic receptor tyrosine kinase 3 (\n                    <jats:italic>NTRK3<\/jats:italic>\n                    ), which supported the cell proliferation of T\u2010ALL cells. Moreover, the overexpression of\n                    <jats:italic>NTRK3<\/jats:italic>\n                    rescued the lactate deficiency\u2010induced proliferation inhibition of T\u2010ALL cells. Furthermore, exogenous lactate supplementation dramatically restored the decreased cell proliferation in T\u2010ALL cells and restored H3K18lac levels. Our findings reveal a novel role of lactate\u2010mediated protein lactylation in regulating T\u2010ALL cell proliferation.\n                  <\/jats:p>","DOI":"10.1002\/jcb.70120","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:09:10Z","timestamp":1788415750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["H3K18 Lactylation Promotes Cell Proliferation in T\u2010Cell Acute Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-5864","authenticated-orcid":false,"given":"Lingling","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Hematology Children's Hospital of Soochow University Suzhou Jiangsu China"},{"name":"Department of Paediatrics Affiliated Maternity and Child Health Care Hospital of Nantong University Nantong Jiangsu 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