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Defining the molecular mechanisms that govern ferroptosis and its effects within the tumor immune microenvironment is critical for understanding its dual role in cancer biology. While modulation of ferroptosis presents a promising therapeutic strategy, non\u2010specific targeting may also impair normal tissues and tumor\u2010infiltrating immune cells. In this context, nanoparticle\u2010based delivery systems offer a potential approach to selectively regulate ferroptosis within tumors. Such strategies may enable precise remodeling of the tumor microenvironment and enhance antitumor immune responses, thereby improving immunotherapy outcomes. This review highlights the regulatory mechanisms linking ferroptosis and the tumor immune microenvironment, provides a critical discussion of recent developments in bionanomaterial\u2010based therapeutic platforms, and outlines the challenges and prospects for clinical application of these platforms for immunotherapy.<\/jats:p>","DOI":"10.1002\/jcb.70125","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:56:48Z","timestamp":1789919808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis in the Tumor Immune Microenvironment: Mechanisms, Nanomedicine, and Immunotherapy"],"prefix":"10.1002","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-7074","authenticated-orcid":false,"given":"Usamah","family":"Sayed","sequence":"first","affiliation":[{"name":"Faculty of Allied Medical Sciences, Hourani Center for Applied Scientific Research Al\u2010Ahliyya 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