{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:51:43Z","timestamp":1791129103727,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cellular Biochemistry"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chondrocyte senescence is a central driver of osteoarthritis (OA) pathogenesis. While bone marrow mesenchymal stem cell\u2010derived exosomes (BMSCs\u2010Exos) exhibit therapeutic potential, their key functional components remain unclear. We therefore investigated\u00a0whether Exportin\u20107 (XPO7), a protein enriched in BMSCs\u2010Exos, alleviates OA by ameliorating chondrocyte senescence\u2010associated changes and explores the underlying mechanism. Using an IL\u20101\u03b2\u2010induced in vitro OA model in rat chondrocytes, we treated cells with exosomes from BMSCs with modulated XPO7 overexpression or knockdown; KDM2B was overexpressed in chondrocytes. Senescence, apoptosis, viability, senescence\u2010associated secretory phenotype (SASP) markers, and extracellular matrix (ECM) metabolism were evaluated. We found that BMSCs\u2010Exos significantly mitigated IL\u20101\u03b2\u2010induced chondrocyte senescence\u2010like changes, apoptosis, SASP (p16, p21, p53, IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1), and ECM degradation, as evidenced by the reversal of IL\u20101\u03b2\u2010induced suppression of anabolic genes SOX9, COL2, ACAN and elevated catabolic gene MMP13. These protective effects were enhanced by XPO7 overexpression and diminished by its knockdown. Co\u2010immunoprecipitation and immunofluorescence further showed that XPO7 physically interacted with and negatively regulated the histone demethylase KDM2B, and overexpressing KDM2B abolished the protective effects of XPO7\u2010enriched exosomes. In an in vivo rat OA model induced by anterior cruciate ligament transection (ACLT), systemic administration of BMSCs\u2010Exos overexpressing XPO7 attenuated cartilage destruction and improved mechanical allodynia (increased paw withdrawal threshold). These therapeutic benefits were significantly reversed by concurrent intra\u2010articular injection with a KDM2B overexpressing plasmid. Collectively, BMSCs\u2010Exos deliver XPO7, which negatively regulates KDM2B to attenuate chondrocyte senescence\u2010associated phenotypes and OA progression. The XPO7\u2010KDM2B axis may represent a promising therapeutic target for OA intervention.<\/jats:p>","DOI":"10.1002\/jcb.70130","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:52:51Z","timestamp":1791125571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BMSCs\u2010Derived Exosomal XPO7 Attenuates Osteoarthritis Progression by Targeting KDM2B to Ameliorate Chondrocyte Senescence"],"prefix":"10.1002","volume":"127","author":[{"given":"Xiaodong","family":"Mao","sequence":"first","affiliation":[{"name":"Fifth Department of Orthopedics and Traumatology, Tianxin Campus, Changsha Hospital of Traditional Chinese Medicine Changsha Eighth Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Che","sequence":"additional","affiliation":[{"name":"Fifth Department of Orthopedics and Traumatology, Tianxin Campus, Changsha Hospital of Traditional Chinese Medicine Changsha Eighth Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fourth Department of Orthopedics and Traumatology, Tianxin Campus, Changsha Hospital of Traditional Chinese Medicine Changsha Eighth Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tan","sequence":"additional","affiliation":[{"name":"Fourth Department of Orthopedics and Traumatology, Tianxin Campus, Changsha Hospital of Traditional Chinese Medicine Changsha Eighth Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4483-7270","authenticated-orcid":false,"given":"Zhengzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Fifth Department of Orthopedics and Traumatology, Tianxin Campus, Changsha Hospital of Traditional Chinese Medicine Changsha Eighth Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"10472","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0140-6736(24)02322-5","article-title":"Osteoarthritis","volume":"405","author":"Kloppenburg M.","year":"2025","journal-title":"Lancet"},{"issue":"9","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, Regional, and National Burden of Osteoarthritis, 1990\u20132020 and Projections to 2050: a Systematic Analysis for the Global Burden of Disease Study 2021","volume":"5","author":"Steinmetz J. 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