{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T13:40:15Z","timestamp":1736948415991,"version":"3.33.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T00:00:00Z","timestamp":1134000000000},"content-version":"vor","delay-in-days":6185,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum pregnancy\u2010associated \u03b1<jats:sub>2<\/jats:sub>\u2010glyco\u2010protein (\u03b1<jats:sub>2<\/jats:sub>\u2010PAG) levels were evaluated in a follow\u2010up study of patients with hepatitis B virus (HBV) infection and compared with biochemical and virological parameters. In a study of 25 patients with acute hepatitis, an association was found between high a<jats:sub>2<\/jats:sub>\u2010PAG values, ALT levels, and HB<jats:sub>s<\/jats:sub>Ag in 20 patients (80%) (<jats:italic>P<\/jats:italic>&lt;0.05), 18 recovered completely, and 2 had a protracted course. In five patients serum a<jats:sub>2<\/jats:sub>\u2010PAG levels were similar to those in the control group. On the other hand, eight (100%) chronic persistent HEW patients showed high levels of \u03b1<jats:sub>2<\/jats:sub>\u2010PAG (P &lt; 0.05) during the study period, and these levels correlated well with inflammatory activity and failure of HB<jats:sub>s<\/jats:sub>Ag elimination. There were no significant differences in \u03b1<jats:sub>2<\/jats:sub>\u2010PAG values between asymptomatic HB<jats:sub>s<\/jats:sub>Ag carriers and controls.<\/jats:p><jats:p>Serial analysis of \u03b1<jats:sub>2<\/jats:sub>\u2010PAG, in correlation with viral markers, biochemical parameters, and histological data, would contribute to the ability to predict the final outcome of HBV infection.<\/jats:p>","DOI":"10.1002\/jcla.1860030202","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T19:32:15Z","timestamp":1173123135000},"page":"73-77","source":"Crossref","is-referenced-by-count":0,"title":["Serum pregnancy\u2010associated \u03b1<sub>2<\/sub>\u2010glycoprotein levels in the evolution of Hepatitis B virus infection"],"prefix":"10.1002","volume":"3","author":[{"given":"Jorge A.","family":"Zarzur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Aldao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santos","family":"Sileoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Vides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"151","volume-title":"Virus and the Liver","author":"De Groote J","year":"1979"},{"key":"e_1_2_1_3_2","first-page":"197","volume-title":"Virus and the Liver","author":"Bianchi L","year":"1979"},{"key":"e_1_2_1_4_2","first-page":"135","volume-title":"Viral Hepatitis and Liver Disease","author":"Di enstag JL","year":"1984"},{"key":"e_1_2_1_5_2","first-page":"1009","volume-title":"Clinical Immunology WB","author":"Eddleston ALWF","year":"1980"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0676.1982.tb00210.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840020506"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/hep.1840030504","article-title":"Immunosuppressive serum factors in viral hepatitis. 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