{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:30:37Z","timestamp":1770478237632,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,8]],"date-time":"2005-12-08T00:00:00Z","timestamp":1134000000000},"content-version":"vor","delay-in-days":6185,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral\u2010blood leukemic cells from 45 patients with peroxidase negative acute lymphoblastic leukemia (ALL), which did not express either myeloid or megakaryocyte\u2010platelet\u2010related cell surface antigens, were analyzed by using monoclonal antibodies capable of recognizing T\u2010 or B\u2010cell\u2010associated and\/or T\u2010 or 6\u2010cell\u2010restricted antigens. Numerous subclasses of ALL, including B\u2010cell lineage leukemias and T\u2010cell lineage leukemias, were identified phenotypically and immunophenotypically in an effort to more accurately characterize the heterogeneous ALLs, their states of differentiation, and their relationships to normal B\u2010 and T\u2010lymphoid cells. Among the cases studied, only seven (15.6%) were found to have stem cell (undifferentiated) leukemia (la<jats:sup>+<\/jats:sup>, CD24<jats:sup>+<\/jats:sup>, CD9<jats:sup>+<\/jats:sup>, CD34<jats:sup>+<\/jats:sup>). It is concluded that the use of monoclonal antibodies for the characterization of heterogeneous ALLs improves the specificity of leukemia classification, which may contribute to the selection of more effective forms of therapy for the types of leukemia identified.<\/jats:p>","DOI":"10.1002\/jcla.1860030205","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T19:32:15Z","timestamp":1173123135000},"page":"88-94","source":"Crossref","is-referenced-by-count":18,"title":["Analysis of peroxidase negative acute leukemias by monoclonal antibodies: III. Acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"3","author":[{"given":"Nobutaka","family":"Imamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kuramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,8]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02684.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1588"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V63.6.1424.1424"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V60.1.1.1"},{"key":"e_1_2_1_7_2","unstructured":"ImamuraN KusunokiY KajiharaH KuramotoA: Flow cytometric analysis of human leukemia by monoclonal antibodies. 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