{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:05:44Z","timestamp":1698037544748},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":5824,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soluble interleukin\u20102 receptor (sIL\u20102R) levels were quantitated in the seum and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and degenerative joint disease (DJD). A sandwich immunoassay, employing two monoclonal antiodies against distinct epitopes on the IL\u20102R, was utilized for measurement. We found a striking elevation of sIL\u20102R in RA SF as compared with DJD SF (RA, 1319 \u00b1 135; DJD, 416 \u00b1 59; p &lt; 0.001). RA serum sIL\u20102R levels were also significantly elevated over DJD levels. There was no interaction between rheumatoid factor (RF) and sIL\u20102R. RA patients with elevated sIL\u20102R levels had significantly longer disease duration, higher c\u2010reactive protein (CRP) levels in serum and SF, and higher RF levels in serum and SF. The groups were similar in regard to other laboratory variables. The presence of elevated levels of sIL\u20102R in RA serum and SF confirms the presence of a heightened immune reactivity and in vivo activation of lymphocytes in RA.<\/jats:p>","DOI":"10.1002\/jcla.1860040211","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T19:46:17Z","timestamp":1173123977000},"page":"130-134","source":"Crossref","is-referenced-by-count":4,"title":["Soluble interleukin\u20102 receptor: Elevated levels in serum and synovial fluid of patients with rheumatoid arthritis"],"prefix":"10.1002","volume":"4","author":[{"given":"A. B.","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Eisenbeis, Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Carrabis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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