{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:14:25Z","timestamp":1760577265264},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:00:00Z","timestamp":1134086400000},"content-version":"vor","delay-in-days":5821,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bence Jones proteins (monoclonal free light chains of immunoglobulins) are the earliest known biological markers of malignant cell dyscrasia; Bence Jones proteinuria is also present in many types of B cell\u2010related neoplasms. Sometimes, it may also occur in Hodgkin's disease. In some cases, benign monoclonal gammopathy was found to be associated nontumorous diseases as well. The type of monoclonal light chain, the degree of polymerization, and the isoelectric point of the molecule may affect the course of the disease. Urine samples from 637 patients with true or suspected lymphoproliferative diseases were investigated over a 2\u2010yr period by different immunochemical methods. Bence Jones proteinuria was identified in 71 cases by isoelectric focusing combined with immunofixation, while the pathological protein was detected only in 63 cases by conventional methods. Bence Jones proteins can be detected by this new method at a level below the sensitivity of conventional procedures. Bence Jones proteins in the urine may signal a malignant tumor or malignant transformation of an earlier disease. The early detection of monoclonal immunoglobulin light chains in the urine may be important in clinical diagnosis, therapy, and follow\u2010up.<\/jats:p>","DOI":"10.1002\/jcla.1860040610","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T19:57:13Z","timestamp":1173124633000},"page":"443-448","source":"Crossref","is-referenced-by-count":6,"title":["Monoclonal free light chains in urine and their significance in clinical diagnostics: Are they really tumor markers?"],"prefix":"10.1002","volume":"4","author":[{"given":"Zsuzsa","family":"V\u00e9gh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Ott\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ndor","family":"Eckhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1974.tb01037.x"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"Immunologic classification of leukemia and lymphoma: Review","volume":"68","author":"Foon KA","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_4_2","first-page":"1563","article-title":"Investigation of monoclonal gammopathies by immunochemical methods: Anachronism or research perspective","volume":"116","author":"Gergely J","year":"1975","journal-title":"Orvosi Hetilap"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207409"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000207723"},{"key":"e_1_2_1_7_2","first-page":"65","article-title":"Amyloidosis: Its nature and pathogenesis","volume":"10","author":"Glenner GG","year":"1973","journal-title":"Semin Hematol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90601-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/ajcp\/82.5.627","article-title":"Polymeric (presumed tetrameric) lambda Bence Jones proteinemia without proteinuria in patient with multiple myeloma A","volume":"82","author":"Ben LH","year":"1984","journal-title":"J Clin Pathol"},{"key":"e_1_2_1_10_2","first-page":"60","article-title":"Nierenkrankungen bei monoklonalen gammopathien\u2010eine klinisch\u2014Pathologische studie","volume":"9","author":"J\u00e1k\u00f3 J","year":"1981","journal-title":"Immunol Infect"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/clinchem\/31.3.475","article-title":"Light chain disease and massive proteinuria","volume":"31","author":"Lessard F","year":"1985","journal-title":"Clin Chem"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1182\/blood.V37.4.473.473","article-title":"Primary amyloidosis with plasmacytic dyscrasia and tetramer of Bence Jones type lambda globulin in the serum and urine","volume":"37","author":"Parr MD","year":"1971","journal-title":"Blood"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1979.137"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.122"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1985.8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(83)90005-6"},{"key":"e_1_2_1_17_2","first-page":"1","article-title":"Detection and immunochemical investigation of the protein components of biological fluids","volume":"28","author":"Ott\u00f3 S","year":"1984","journal-title":"Magy Onkol"},{"key":"e_1_2_1_18_2","first-page":"893","article-title":"Gamma\u2010chain heavy chain disease with primary thyroid plasmacytoma","volume":"110","author":"Ott\u00f3 S","year":"1986","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(84)90080-4"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.8.779"},{"key":"e_1_2_1_21_2","first-page":"289","article-title":"Immunofixation electrophoresis: An immunochemical method for testing protein anomalies","volume":"17","author":"Ott\u00f3 S","year":"1984","journal-title":"Haematologia"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.3.255"},{"key":"e_1_2_1_23_2","first-page":"41","article-title":"Isoelectrofocusing\u2014An up\u2010to\u2010date method for the study of monoclonal immunoglobulins. 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