{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:42:29Z","timestamp":1784194949550,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":5406,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[1991,1]]},"abstract":"Abstract<\/jats:title>We sought to determine if Histoplasma capsulatum<\/jats:italic> polysaccharide antigen (HPA) levels correlate with the extent of infection in murine of histoplasmosis. Separate groups of mice were inoculated intratracheally with varying numbers of H. capsulatum<\/jats:italic> yeast cells. After 1 week, HPA levels and fungal burden (quantitative culture of lung and spleen and histopathologic stain of lung) were determined in lung and spleen, and HPA levels in serum. HPA levels, cultures and histopathological stain results of lung and spleen tissue showed a direct correlation with increasing inoculum size. HPA levels in serum also correlated with the size of inoculum. H. capsulatum<\/jats:italic> antigen in lung correlated with silver stain scores of lung tissue, (R = 0.948, P<\/jats:italic> <0.001) and with quantitative culture scores of lung, (R = 0.929, P<\/jats:italic> <0.001). HPA levels in spleen tissue also correlated with spleen culture scores, (R = 0.724, P<\/jats:italic> <0.001). These results indicate that determination of HPA level in serum and tissue may be a useful test in evaluating the severity of diseases as well as efficacy of antifungal therapy in histoplasmosis.<\/jats:p>","DOI":"10.1002\/jcla.1860050209","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T20:12:23Z","timestamp":1173125543000},"page":"121-126","source":"Crossref","is-referenced-by-count":10,"title":["Correlation of histoplasma capsulatum<\/i> polysaccharide antigen with the severity of infection in murine histoplasmosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Brian J.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Connolly\u2010Stringfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Durkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robinette","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Joseph","family":"Wheat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Garringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram P.","family":"Tewari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0891-5520(20)30231-2","article-title":"Histoplasmosis","volume":"2","author":"Wheat LJ","year":"1988","journal-title":"Infect Dis Clin North Am"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1128\/jcm.23.3.493-499.1986","article-title":"Evaluation of cross reactions in Histoplasma serologic test","volume":"23","author":"Wheat LJ","year":"1986","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198601093140205"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(89)80820-4"},{"key":"e_1_2_1_6_2","first-page":"768","article-title":"Treatment of murine histoplasmosis with UK 49,858 (Fluconazole)","volume":"134","author":"Graybill JR","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.29.4.660"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.4.551"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.4.967"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.4.678"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.1860050209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.1860050209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:53:26Z","timestamp":1698040406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.1860050209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/jcla.1860050209"],"URL":"https:\/\/doi.org\/10.1002\/jcla.1860050209","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}