{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:26:25Z","timestamp":1791163585690,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":5406,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary Sj\u00f6gren's syndrome (1\u00b0 SS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary glands and autoantibody production. In order to identify genetic factors that play a role in pathogenesis and predict extent of disease, we used Southern blot and polymerase chain reaction (PCR) methods to detect polymorphisms of the HLA\u2010DRB1 (DR), HLA\u2010DRB3 (DRw52), and HLA\u2010DQA1 genes among 75 Caucasoid 1\u00b0 SS patients and 150 Caucasoid controls living in the same geographic region of Southern California. We found significantly increased frequency of HLA\u2010DR3 (<jats:italic>P<\/jats:italic> &lt; .001), HLA\u2010DW52a (<jats:italic>P<\/jats:italic> &lt; .001), and HLA\u2010DQA4 (<jats:italic>P<\/jats:italic> &lt; .05), in comparison to normal controls. Also, an increased frequency of heterozygosity for HLA\u2010DQA1\/DQA4(<jats:italic>P<\/jats:italic> &lt; .05) was present among 1\u00b0 SS patients. Autoantibodies to SS\u2010A and to SS\u2010B were significantly associated with DR3 (<jats:italic>P<\/jats:italic> &lt; .001), HLA\u2010DQA4, (<jats:italic>P<\/jats:italic> &lt; .05), and DQA4\/DQA1 heterozygotes (<jats:italic>P<\/jats:italic> &lt; .01). Among the 1\u00b0 SS patients, clinical and laboratory features such as hypergammaglobulinemia, symmetric peripheral neuropathy, and hypothyroidism were significantly associated with HLA\u2010DR3 (<jats:italic>P<\/jats:italic> &lt; .01) but not with HLA\u2010DR2 (<jats:italic>P<\/jats:italic> &gt; .10). In comparison, 1\u00b0 SS patients with leukocytoclastic vasculitis were more frequently HLA\u2010DR2 (<jats:italic>P<\/jats:italic> &lt; .05). These results using PCR methods confirm and extend prior studies that have used serologic methods.<\/jats:p>","DOI":"10.1002\/jcla.1860050604","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T20:01:32Z","timestamp":1173124892000},"page":"382-391","source":"Crossref","is-referenced-by-count":30,"title":["Specific hla\u2010dqa and hla\u2010drb1 alleles confer susceptibility to sj\u00f6gren's syndrome and autoantibody production"],"prefix":"10.1002","volume":"5","author":[{"given":"Hong Ming","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoil","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Peebles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Scharf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Erlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196505000-00001"},{"key":"e_1_2_1_3_2","first-page":"279","article-title":"Sj\u00f6gren's syndrome. 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