{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:12:13Z","timestamp":1785352333955,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":136,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin 6 (IL\u20106) may represent an early marker of inflammatory activation and may be useful to ameliorate risk stratification in patients with ischemic heart disease. The aim of this study was to verify the performance characteristics of an ultrasensitive immunoassay (Biosource International, Camarillo, CA) for high\u2010sensitivity (hs)\u2010IL\u20106 measurement in comparison with hs\u2010R&amp;D Systems (Abingdon, United Kingdom) and Immulite System (Diagnostic Products Corporation [DPC], Los Angeles, CA) methods in patients with ischemic heart disease. In addition, hs\u2013C\u2010reactive protein (hs\u2010CRP) concentrations were measured, to evaluate the correlation with hs\u2010IL\u20106 levels. We measured IL\u20106 and CRP serum levels in 39 patients with ischemic heart disease and in 12 controls. Out of the 39 patients studied, 13 were affected by unstable angina, 13 by post\u2013acute myocardial infarction (AMI) unstable angina, and 13 by stable angina. The imprecision profile and functional sensitivity were performed measuring 9 different serum pools in 10 runs. The Biosource method had the best performance characteristics as compared to the others. Mean IL\u20106 level was higher in patients with unstable and post\u2010AMI unstable angina with respect to controls. CRP levels were elevated in patients with post\u2010AMI. In the whole population a high significant linear regression was observed between Biosource hs\u2010IL\u20106 and hs\u2010CRP serum levels. The Biosource method for IL\u20106 measurement is characterized by a high functional sensitivity that allows a better stratification of patients with ischemic heart disease. J. Clin. Lab. Anal. 19:110\u2013114, 2005. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20061","type":"journal-article","created":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T19:46:46Z","timestamp":1116359206000},"page":"110-114","source":"Crossref","is-referenced-by-count":37,"title":["Usefulness of high\u2010sensitivity IL\u20106 measurement for clinical characterization of patients with coronary artery disease"],"prefix":"10.1002","volume":"19","author":[{"given":"Valter","family":"Lubrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Cocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Battaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Papa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Marraccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Carlo","family":"Zucchelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.124414"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.36"},{"key":"e_1_2_1_4_2","first-page":"147","article-title":"Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation","volume":"7","author":"Baumann H","year":"1990","journal-title":"Mol Biol Med"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.17.2107"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.4.1253"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200303133481115"},{"key":"e_1_2_1_8_2","first-page":"2453","article-title":"C\u2010reactive protein","volume":"162","author":"Jensen HS","year":"2000","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3251"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00134-4"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(95)11708-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00703-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00348-4"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(20000215)19:3<313::AID-SIM370>3.0.CO;2-K"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.5.874"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.10.033"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1182\/blood.V86.4.1243.bloodjournal8641243","article-title":"Interleukin 6 family of cytokines and gp130","volume":"86","author":"Kishimoto T","year":"1995","journal-title":"Blood"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(90)90003-C"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.75.1.181"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1182\/blood.V91.1.258","article-title":"Interleukin 6 induces monocyte chemotactic protein\u20101 in peripheral blood mononuclear cells and in the U937 cell line","volume":"91","author":"Biswas P","year":"1998","journal-title":"Blood"},{"key":"e_1_2_1_22_2","first-page":"15","article-title":"The interplay between primary and secondary cytokines. 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