{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:55:30Z","timestamp":1758120930790},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T00:00:00Z","timestamp":1174867200000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present study we examined the utility of measuring antigen\u2010specific soluble immune complexes (ICs) for the differential diagnosis and therapeutic monitoring of Bancroftian filariasis. Antigen\u2010specific ICs were detected in significantly elevated levels in 90% of lymphatic filarial subjects suffering from disease manifestations, and very low levels in 8\u201310% of microfilaria (MF) carriers. The high incidence of antigen\u2010specific ICs in the circulation of filarial subjects with clinical manifestations in contrast to the negligible presence in MF carriers facilitates serological differentiation of these two important stages of lymphatic filarial infection. A sudden spurt in circulating levels of antigen\u2010specific ICs was recorded in all MF carriers on diethylcarbamazine (DEC) therapy, and the magnitude of the increase correlated positively with the pretreatment levels of circulating MF. Thus, it is evident from the present study that circulating ICs (CICs) are potential serological markers for both the differential diagnosis of filarial infection and therapeutic monitoring of MF carriers. J. Clin. Lab. Anal. 21:114\u2013118, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20116","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T20:13:53Z","timestamp":1174940033000},"page":"114-118","source":"Crossref","is-referenced-by-count":7,"title":["Serum immune complexes as diagnostic and therapeutic markers in lymphatic filariasis"],"prefix":"10.1002","volume":"21","author":[{"given":"Vandana","family":"Dixit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.S.","family":"Bisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.B.K.S.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.C.","family":"Harinath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02702711"},{"key":"e_1_2_1_3_2","first-page":"343","article-title":"Effect of different DEC schedules on microfilaraemia and filarial antibody levels in bancroftian filariasis","volume":"78","author":"Malhotra A","year":"1983","journal-title":"Ind J Med Res"},{"key":"e_1_2_1_4_2","first-page":"425","article-title":"Detection of filarial immune complexes by ELISA using anti\u2010C3 and filarial serum immunoglobulin\u2010G","volume":"12","author":"Prasad GBKS","year":"1984","journal-title":"IRCS Med Sci"},{"key":"e_1_2_1_5_2","first-page":"1055","article-title":"Immune complexes in Wuchereria bancrofti filariasis specific for phosphoryl choline and infective larval antigens","volume":"16","author":"Das MK","year":"1988","journal-title":"Med Sci Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1987.tb00522.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00202556"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000313795"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(69)90177-3"},{"key":"e_1_2_1_11_2","first-page":"403","article-title":"A highly specific and sensitive monoclonal antibody\u2010based ELISA for the detection of circulating antigen in bancroftian filariasis","volume":"41","author":"More SJ","year":"1990","journal-title":"Trop Med Parasitol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.1.247"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00027103"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(98)91068-9"},{"key":"e_1_2_1_15_2","first-page":"355","article-title":"Assessment of immunochromatographic test for rapid lymphatic filariasis diagnosis","volume":"6","author":"Nguyen NL","year":"1999","journal-title":"Parasitology"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050531"},{"key":"e_1_2_1_17_2","first-page":"194","article-title":"Detection and monitoring of microfilarial ES antigen levels by inhibition ELISA during DEC therapy","volume":"79","author":"Malhotra A","year":"1984","journal-title":"Ind J Med Res"},{"key":"e_1_2_1_18_2","first-page":"49","article-title":"Utility and durability of finger\u2010prick blood samples collected on Whatman filter paper for detection of immune complexes by ELISA","volume":"4","author":"Madhu E","year":"1995","journal-title":"J Parasitol Appl Anim Biol"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.20116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.20116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T13:30:46Z","timestamp":1699968646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.20116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/jcla.20116"],"URL":"https:\/\/doi.org\/10.1002\/jcla.20116","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}