{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:59:02Z","timestamp":1774871942807,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,7,9]],"date-time":"2007-07-09T00:00:00Z","timestamp":1183939200000},"content-version":"vor","delay-in-days":189,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new spectrofluorimetric method was developed for the determination of trace amounts of bile acid (BA). Using europium ion (Eu<jats:sup>3+<\/jats:sup>)\u2010doxycycline (DC) as a fluorescent probe, in a buffer solution of pH=7.0, BA can remarkably reduce the fluorescence intensity of the DC\u2010Eu<jats:sup>3+<\/jats:sup> complex at \u03bb=612 nm; the reduced fluorescence intensity of the Eu<jats:sup>3+<\/jats:sup> is proportional to the concentration of BA. Optimum conditions for the determination of BA were also investigated. The linear range and detection limit for the determination of BA were 5.0 \u00d7 10<jats:sup>\u22128<\/jats:sup>\u2009mol\/L to 5.5 \u00d7 10<jats:sup>\u22127<\/jats:sup>\u2009mol\/L and 1.1 \u00d7 10<jats:sup>\u22128<\/jats:sup>\u2009mol\/L, respectively. This method is practical and relatively free of interference from coexisting substances, and can be successfully applied to assess BA in serum samples. J. Clin. Lab. Anal. 21:207\u2013212, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20137","type":"journal-article","created":{"date-parts":[[2007,7,9]],"date-time":"2007-07-09T23:51:25Z","timestamp":1184025085000},"page":"207-212","source":"Crossref","is-referenced-by-count":8,"title":["Spectrofluorimetric determination of bile acid using a europium\u2010doxycycline probe"],"prefix":"10.1002","volume":"21","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongqiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,7,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32342-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/211816a0"},{"key":"e_1_2_1_4_2","volume-title":"Progress in liver diseases","author":"Herdisen WGM","year":"1978"},{"key":"e_1_2_1_5_2","first-page":"684","volume-title":"Clinical Experimental Diagnostics","author":"Yie YW","year":"1989"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/29.1.171"},{"key":"e_1_2_1_7_2","first-page":"56","volume-title":"China Pharmacopoeia","author":"Chinese Sanitation Ministry Pharmacopoeia Committee","year":"1995"},{"key":"e_1_2_1_8_2","first-page":"69","volume-title":"The quality criterion of Chinese traditional patent medicine and the investigation of reference material","author":"Wang BQ","year":"1994"},{"key":"e_1_2_1_9_2","first-page":"971","article-title":"Bile acids in tissues: Binding of lithocholic acid to protein","volume":"13","author":"Shau R","year":"1978","journal-title":"Lipids"},{"key":"e_1_2_1_10_2","first-page":"913","article-title":"A new bile acid radioimmunoassay: Development, validation, and preliminary application of an assay for chenodeoxychotyl conjugates","volume":"68","author":"Schalm SW","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_11_2","first-page":"1100","article-title":"Determination of bile acids from extracted serum by high performance liquid chromatography\u2010mass spectrometry with fluorescence detection","volume":"33","author":"Shi YW","year":"2005","journal-title":"Chin J Anal Chem"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(95)00215-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)84864-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0022-2275(20)38266-3","article-title":"Thermo spray ionization liquid chromatography\u2010mass spectrometry: a new and highly specific technique for the analysis of bile acids","volume":"30","author":"Setchell K","year":"1989","journal-title":"J Lipid Res"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(94)00544-F"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(76)90007-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2004.01.043"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2003.11.013"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(03)00356-7"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-003-0087-0"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2005.03.014"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac0013305"},{"key":"e_1_2_1_23_2","first-page":"11","article-title":"Quantitative determination of cholic acid in niuhuangqinxin pill by TLC\u2010densitometry","volume":"3","author":"Wang CF","year":"1997","journal-title":"Chin J Exp Tradit Med Formulae"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.20137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.20137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T12:31:44Z","timestamp":1699965104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.20137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1002\/jcla.20137"],"URL":"https:\/\/doi.org\/10.1002\/jcla.20137","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}