{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:07:21Z","timestamp":1785539241670,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T00:00:00Z","timestamp":1179273600000},"content-version":"vor","delay-in-days":135,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The presence of high\u2010molecular intestinal alkaline phosphatase (HIALP) different from bone ALP detected in the \u03b1<jats:sub>2<\/jats:sub>\u03b2 region was recently clarified. In this study we used a novel method in which HIALP was detected after conversion to ALP<jats:sub>5<\/jats:sub> by protease to investigate the clinical significance of the appearance of HIALP in patients with chronic liver disease. The subjects were 241 patients with chronic liver disease. When a decrease in ALP<jats:sub>3<\/jats:sub> in the \u03b1<jats:sub>2<\/jats:sub>\u03b2 region and an increase in ALP<jats:sub>5<\/jats:sub> in the \u03b2 region were noted, the patient was judged HIALP\u2010positive. In the patients with chronic liver disease, the total ALP activity (T\u2010ALP) increased with progression of the pathology in the order of chronic hepatitis (CH), liver cirrhosis (LC), and hepatocellularcarcinoma (HCC). HIALP appeared in 22.4% and 49.3% of patients with CH and LC, respectively, but the positivity rate decreased to 30.4% in HCC. As autoimmune liver diseases, primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH) were investigated. T\u2010ALP was lower in PBC+AIH than in LC and HCC, but the HIALP\u2010positive rate was high (44.4%). The HIALP\u2010positive rate was dependent on ABO blood groups, and was high in blood groups B and O. In conclusion, the HIALP\u2010positive rate was particularly high in patients with chronic liver disease, and was related to the pathological progression, which suggests that the method is clinically useful. J. Clin. Lab. Anal. 21:133\u2013139, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20178","type":"journal-article","created":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T22:50:10Z","timestamp":1179355810000},"page":"133-139","source":"Crossref","is-referenced-by-count":190,"title":["High\u2010molecular intestinal alkaline phosphatase in chronic liver 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