{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:06:34Z","timestamp":1700006794818},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T00:00:00Z","timestamp":1221782400000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coeliac disease (CD) screening has progressed rapidly with tissue transglutaminase (TTG), the screening tool of choice. However, TTG may be unreliable in young children and advances in CD etiology understanding have seen improvements in anti\u2010gliadin (AGA) assay technology. The aim of this study was to investigate the utility of an updated and refined AGA (Neogliadin) assay for CD screening in children with gastrointestinal symptoms. Children attending the Sydney Children's Hospital, Randwick, with gastrointestinal symptoms had sera collected and assayed by Neogliadin and commercial TTG assays in addition to the usual clinical work\u2010up. One hundred and fifteen children were recruited in which 32 were diagnosed with CD. AGA\u2013IgA screening by Neogliadin showed improved sensitivity (83%) and specificity (91%) but did not eclipse the sensitivity (93%) and specificity (90%) of TTG\u2013IgA screening. In the children diagnosed with CD, 7 were identified as younger than 5 years of age with 4\/7 AGA\u2013IgA positive, 5\/7 AGA\u2013IgG positive, and 6\/7 TTG\u2013IgA positive. The updated Neogliadin IgA assay does not improve on the accuracy achieved by TTG screening. TTG appears to be a suitable screening tool for children younger than 5 years of age although this preliminary finding requires confirmation. J. Clin. Lab. Anal. 22:327\u2013333, 2008. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20263","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T16:52:32Z","timestamp":1221843152000},"page":"327-333","source":"Crossref","is-referenced-by-count":2,"title":["Coeliac disease screening in children: assessment of a novel anti\u2010gliadin antibody assay"],"prefix":"10.1002","volume":"22","author":[{"given":"Steven T.","family":"Leach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brekhna","family":"Aurangzeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2007.01.001"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2005.02.004"},{"key":"e_1_2_1_4_2","volume-title":"Principles and Practice for Screening Disease","author":"Wilson JM","year":"1968"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.012"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.8.909"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310007530"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200605000-00006"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.028"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0698-713"},{"key":"e_1_2_1_11_2","first-page":"613","volume-title":"Pediatric Gastorintestinal Disease","author":"Griffiths AM","year":"2000"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7435.322"},{"key":"e_1_2_1_14_2","first-page":"12","article-title":"Coeliac disease diagnosed at Starship Children's Hospital: 1999\u20132002","volume":"118","author":"Westerbeek E","year":"2005","journal-title":"N Z Med J"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200407000-00016"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31806c7b34"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.1.150-151.2006"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.05.004"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701452217"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.05.024"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.20263","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.20263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T19:47:42Z","timestamp":1699991262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.20263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1002\/jcla.20263"],"URL":"https:\/\/doi.org\/10.1002\/jcla.20263","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}