{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:08:13Z","timestamp":1700006893589},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T00:00:00Z","timestamp":1242691200000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was aimed to elucidate the relationship between major blood group antigens (BGAs) and susceptibility or resistance to human lymphatic filariasis. A total of 492 human subjects, living in Raipur city of Chhattisgarh, endemic for bancroftian filariasis in Central India, were screened for the presence of <jats:italic>Wuchereria bancrofti<\/jats:italic> microfilariae and disease manifestations. The frequency of BGAs was tabulated as a function of the status of filariasis, namely normal (no infection), mf carrier (presence of microfilariae in blood), and elephantiasis (confirmed clinical manifestations). The comparison of ABO phenotype distributions among all the three groups clearly indicated that disease status has a significant relationship with the blood group attributes. The result of \u03c7<jats:sup>2<\/jats:sup> analysis of the frequencies of ABO phenotypes observed in microfilaraemic and elephantiasis groups (observed frequency vs. expected frequency computed based on the distribution of the normal population) revealed that there has been a significant alteration in the distribution of ABO phenotypes in microfilaraemic, but not in elephantiasis, group. The susceptibility to filarial infection was computed as a function of blood group phenotypes in the population. The susceptibility and conditional susceptibility for elephantiasis were the least among the subjects with AB phenotypes. The mechanism of association between filariasis and ABO antigens needs to be further explored to understand how the distribution of BGAs affects susceptibility\/resistance to infection. J. Clin. Lab. Anal. 23:186\u2013191, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20317","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T17:59:49Z","timestamp":1242755989000},"page":"186-191","source":"Crossref","is-referenced-by-count":1,"title":["Filarial infection is resisted differentially by subjects having different blood group phenotypes"],"prefix":"10.1002","volume":"23","author":[{"given":"Vandana","family":"Dixit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Pati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.S.","family":"Bisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.B.K.S.","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,19]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"World Health Report World Health Organization 1999. 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Proceedings of the All India Symposium on Vectors and Vectors\u2010Borne Diseases Trivandrum India February 26\u201028.1982. p 155\u2013158."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-62-15355"},{"key":"e_1_2_1_13_2","first-page":"119","article-title":"Blood group and filariasis","volume":"7","author":"Nair CP","year":"1959","journal-title":"Bull Natl Soc India Malar Other Mosq Borne Dis"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(83)90141-4"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(85)90089-6"},{"key":"e_1_2_1_16_2","unstructured":"PaniSP DasLK SadanandaneC BalakrishnanN SubrahmaniamS.Blood groups and bancroftian filariasis. 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