{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:48:37Z","timestamp":1767887317596,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: N\u2010terminal proBNP (NT\u2010proBNP) is widely used as a diagnostic biomarker and for the risk stratification of patients with heart failure (HF). Its role in the evaluation of patients with essential hypertension (EHT) is less clear. We examined the relationship between NT\u2010proBNP concentrations and various clinical characteristics in hypertensive patients without HF. <jats:italic>Methods<\/jats:italic>: This study included 186 consecutive patients with EHT and no history of HF, ischemic heart disease, or atrial fibrillation. Single and multiple variable regression analyses were performed in search of clinical correlates of NT\u2010proBNP concentrations. <jats:italic>Results<\/jats:italic>: In patients with EHT, median serum concentration of NT\u2010proBNP was 73\u2009pg\/ml, and interquartile range (IQR) was 40\u2013128\u2009pg\/ml. NT\u2010proBNP was significantly higher (<jats:italic>P<\/jats:italic>&lt;0.001) in women (87\u2009pg\/ml; IQR 55\u2013137\u2009pg\/ml) than in men (52\u2009pg\/ml; IQR 24\u2013115\u2009pg\/ml). Age (<jats:italic>r<\/jats:italic>=0.371, <jats:italic>P<\/jats:italic>&lt;0.001), precordial QRS voltage (<jats:italic>r<\/jats:italic>=0.223, <jats:italic>P<\/jats:italic>&lt;0.001), hemoglobin (Hgb) concentration, (<jats:italic>r<\/jats:italic>=\u22120.208, <jats:italic>P<\/jats:italic>=0.023) and estimated glomerular filtration rate (<jats:italic>r<\/jats:italic>=\u22120.139, <jats:italic>P<\/jats:italic>=0.044) were correlated with log\u2010transformed NT\u2010proBNP by multiple variable analysis. In men, age (<jats:italic>r<\/jats:italic>=0.453, <jats:italic>P<\/jats:italic>&lt;0.001) and QRS voltage (<jats:italic>r<\/jats:italic>=0.283, <jats:italic>P<\/jats:italic>=0.004), and in women age (<jats:italic>r<\/jats:italic>=0.299, <jats:italic>P<\/jats:italic>=0.006), QRS voltage (<jats:italic>r<\/jats:italic>=0.212, <jats:italic>P<\/jats:italic>=0.019), Hgb (<jats:italic>r<\/jats:italic>=\u22120.182, <jats:italic>P<\/jats:italic>=0.049), and estimated glomerular filtration rate (<jats:italic>r<\/jats:italic>=\u22120.272, <jats:italic>P<\/jats:italic>=0.009) were correlated with serum concentrations of NT\u2010proBNP. <jats:italic>Conclusions<\/jats:italic>: Age, gender, Hgb, left ventricular hypertrophy and renal function were correlated with NT\u2010proBNP in patients with EHT. J. Clin. Lab. Anal. 24:12\u201316, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20366","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T19:57:43Z","timestamp":1263931063000},"page":"12-16","source":"Crossref","is-referenced-by-count":7,"title":["Correlates of NT\u2010proBNP concentration in patients with essential hypertension in absence of congestive heart failure"],"prefix":"10.1002","volume":"24","author":[{"given":"Keizo","family":"Toda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihito","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenro","family":"Hijiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryutaro","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatuo","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Takatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayoshi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13976-1"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7362"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.185266"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000216794.24161.8c"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00364-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02059-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.04.001"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2003.12.015"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.051"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.032"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1609"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2005.04.015"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.069575"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.07.029"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.4.871"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.49.577"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2005.04.019"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.770"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.20366","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.20366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T15:32:49Z","timestamp":1700580769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.20366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/jcla.20366"],"URL":"https:\/\/doi.org\/10.1002\/jcla.20366","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}