{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:40:43Z","timestamp":1756572043536},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T00:00:00Z","timestamp":1290038400000},"content-version":"vor","delay-in-days":321,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Acute aortic dissection (AOD) is associated with high mortality and early diagnosis and treatment are essential. Ischemia\u2010modified albumin (IMA) is a marker of myocardial ischemia whereas cardiac enzymes are released when myocardial necrosis occurs. We investigated, for the first time, whether IMA increases in AOD either at presentation or after surgery. <jats:italic>Methods<\/jats:italic>: We studied 46 consecutive patients with documented AOD; we also evaluated 13 consecutive patients with dilated ascending aortas scheduled for elective surgery and admitted for preoperative coronary angiography; 46 age\u2010matched normal subjects served as controls. Only patients with acute onset of symptoms were included. We evaluated IMA, cardiac enzymes, <jats:italic>N<\/jats:italic>\u2010terminal pro\u2010B\u2010type natriureticpeptide, albumin, C\u2010reactive protein (CRP), and D\u2010dimers on admission, 24\u2009hr post\u2010operatively and 4 days post\u2010operatively. Duration from symptom onset to the first sample was 23\u00b117\u2009hr. <jats:italic>Results<\/jats:italic>: IMA did not differ between patients with AOD at presentation (93\u00b119\u2009U\/ml), patients with chronic aneurysms (90\u00b114\u2009U\/ml) and normal controls (91\u00b19\u2009U\/ml). In addition, IMA did not change significantly after surgical repair. IMA, at baseline, however, correlated positively with time from symptom onset as well as CRP levels (<jats:italic>P<\/jats:italic>=0.05 and <jats:italic>P<\/jats:italic>=0.007, respectively). <jats:italic>Conclusion<\/jats:italic>: IMA is not elevated in AOD when blood sampling is performed within 23\u00b117\u2009hr after symptom onset nor increases after surgery. J. Clin. Lab. Anal. 24:399\u2013402, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20418","type":"journal-article","created":{"date-parts":[[2010,11,18]],"date-time":"2010-11-18T14:34:39Z","timestamp":1290090879000},"page":"399-402","source":"Crossref","is-referenced-by-count":11,"title":["Ischemia\u2010modified albumin in acute aortic 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