{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:59:31Z","timestamp":1770220771949,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,9,14]],"date-time":"2011-09-14T00:00:00Z","timestamp":1315958400000},"content-version":"vor","delay-in-days":256,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we estimated the reference intervals of the serum homocysteine (Hcy) level using two automated immunoassays, and we demonstrated the effects of various factors on the Hcy level in a Korean population. We calculated the gender\u2010 and assay\u2010specific reference intervals using the data from 809 healthy Koreans, and we assessed the effects of physiologic and lifestyle factors on the Hcy level. The upper limit was higher in males (19.21 and 19.76\u2009\u03bcmol\/l) than that in females (14.99\u2009\u03bcmol\/l and 15.16\u2009\u03bcmol\/l, AxSym and ADVIA centaur, respectively); the upper limits were comparable between the two assays. Smokers, vitamin nonusers, and persons without regular exercise showed a lower folate level and a higher Hcy level. The risk of hyperhomocysteinemia was significantly associated with the male gender (adjusted OR: 5.705, <jats:italic>P<\/jats:italic>\u2010value: 0.008) and with the low folate level group (adjusted OR: 10.412, <jats:italic>P<\/jats:italic>\u2010value: 0.002) on the multivariate analysis. The Hcy level was significantly different according to various factors, especially in the gender and folate level. The reference interval should be determined for each ethnic population and for each assay. The appropriate cutoff for assessing the risk for cardiovascular disease or stroke should also be validated in each population. J. Clin. Lab. Anal. 25:317\u2013323, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcla.20476","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T07:08:46Z","timestamp":1316070526000},"page":"317-323","source":"Crossref","is-referenced-by-count":25,"title":["Reference interval and determinants of the serum homocysteine level in a Korean population"],"prefix":"10.1002","volume":"25","author":[{"given":"Hee\u2010Won","family":"Moon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hee","family":"Whang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Jin","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin Young","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo\u2010Min","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Hur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Q","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530130055028"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03490070059042"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/clinchem\/46.8.1277","article-title":"Cobalamin and folate evaluation: Measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate","volume":"46","author":"Klee GG.","year":"2000","journal-title":"Clin Chem"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.2015"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.021634"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665108007076"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.6.1027"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.3.482"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.2.263"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/42.4.630"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1731S"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2001.111"},{"key":"e_1_2_6_14_2","unstructured":"Clinical and Laboratory Standards Institute. 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