{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:19:52Z","timestamp":1770351592424,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T00:00:00Z","timestamp":1337817600000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>To date, no study reports the implication of YKL\u201040 in pelvic inflammatory disease (PID). Therefore, we investigate the levels of plasma YKL\u201040 in patients with PID and further associate its expression with the severity of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a hospital\u2010based case\u2010control study with approximate 1:1 ratio and consecutively recruited 64 patients with PID and 70 control women. We collected blood samples from 64 women with PID before and after they received treatment and 70 control women to detect levels of plasma YKL\u201040 and C\u2010reactive protein (CRP) as well as white blood cell and neutrophil counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results revealed that levels of plasma YKL\u201040 were significantly elevated in patients with PID as compared to those in controls (38.36 vs. 21.69 ng\/ml, <jats:italic>P<\/jats:italic> = 0.001) but the significant difference was restricted to women aged 30 years or old after age stratification (56.75 vs. 23.61 ng\/ml, <jats:italic>P<\/jats:italic> \u2264 0.001). It declined significantly after they received treatment (median: 38.36 vs. 27.54 ng\/ml; <jats:italic>P<\/jats:italic> \u2264 0.001). Although both plasma YKL\u201040 and CRP were elevated in patients with tubo\u2010ovarian abscess, PID patients with surgery exhibited higher YKL\u201040 concentration than those without surgery (median: 82.05 vs. 30.19 ng\/ml, <jats:italic>P<\/jats:italic> = 0.005) and only plasma YKL\u201040 was significantly associated with the length of the hospital stay (<jats:italic>P<\/jats:italic> \u2264 0.001, <jats:italic>R<\/jats:italic> = 0.604).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that once individuals are diagnosed to have PID, YKL\u201040 may act as a biomarker to predict the severity and clinical outcome of the disease. J. Clin. Lab. Anal. 26:136\u2010142, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21500","type":"journal-article","created":{"date-parts":[[2012,5,24]],"date-time":"2012-05-24T18:55:00Z","timestamp":1337885700000},"page":"136-142","source":"Crossref","is-referenced-by-count":11,"title":["Significant Association of Elevated Concentration of Plasma YKL\u201040 with Disease Severity in Patients With Pelvic Inflammatory Disease"],"prefix":"10.1002","volume":"26","author":[{"given":"Shu\u2010Hsin","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"School of Nursing Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Nursing Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical 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