{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:22:49Z","timestamp":1778736169163,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"Background<\/jats:title>X\u2010ray repair cross\u2010complementing group 1 (XRCC<\/jats:styled-content>1<\/jats:italic>) plays a central role in mammalian DNA<\/jats:styled-content> repair process. The polymorphism rs25487 (Arg>Gln at codon 399) of this gene is common in Han Chinese population.<\/jats:p><\/jats:sec>Objectives<\/jats:title>The objective of this study was to analyze the association between this functional SNP<\/jats:styled-content> of XRCC<\/jats:styled-content>1<\/jats:italic> and Tourette syndrome (TS<\/jats:styled-content>) in Han Taiwan Chinese population.<\/jats:p><\/jats:sec>Methods<\/jats:title>Genotyping was performed by using PCR<\/jats:styled-content>\u2013RFLP<\/jats:styled-content> method on 73 TS<\/jats:styled-content> patients and 158 normal controls.<\/jats:p><\/jats:sec>Results<\/jats:title>Our data indicated that genotype frequency of A<\/jats:styled-content>\/G<\/jats:styled-content> polymorphism at codon 399 of the patients differed from the controls (P<\/jats:styled-content><\/jats:italic> = 0.026, OR<\/jats:styled-content>: 2.22, 95% CI<\/jats:styled-content>: 1.22\u20134.03). The allele frequency analysis also showed significant differences with higher A<\/jats:styled-content> allele frequency in patients (P<\/jats:styled-content><\/jats:italic> = 0.015, OR<\/jats:styled-content>: 1.70, 95% CI<\/jats:styled-content>: 1.11\u20132.62).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study indicates that the functional SNP<\/jats:styled-content> at codon 399 of XRCC<\/jats:styled-content>1<\/jats:italic> is associated with TS<\/jats:styled-content> development. J. Clin. Lab. Anal. 26:321\u2010324, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21525","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T16:05:00Z","timestamp":1348243500000},"page":"321-324","source":"Crossref","is-referenced-by-count":7,"title":["Association of Genetic Variations in X<\/scp>\u2010Ray Repair Cross\u2010Complementing Group 1 and T<\/scp>ourette Syndrome"],"prefix":"10.1002","volume":"26","author":[{"given":"Wei\u2010Yong","family":"Lin","sequence":"first","affiliation":[{"name":"Graduate Institute of Integrated Medicine China Medical University Taichung Taiwan"},{"name":"Department of Medical Research China Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Chun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Research China Medical University Hospital Taichung Taiwan"},{"name":"School of Medicine 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