{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:51:44Z","timestamp":1761663104269},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>The significance of antibodies to cardiolipin (anti\u2010CL) remains uncertain in patients with chronic hepatitis C (CH\u2010C). The main purpose of this study was to elucidate the clinical characteristics of patients with CH\u2010C seropositive for anti\u2010CL. The prevalence of anti\u2010CL and clinical parameters associated with anti\u2010CL in those patients were examined. Six of the 45 (13%) patients with CH\u2010C had anti\u2010CL. However, none of these six CH\u2010C patients fulfilled the criteria for antiphospholipid syndrome. Serum triglyceride and apolipoprotein B (ApoB) levels in CH\u2010C patients with anti\u2010CL were significantly higher than those in CH\u2010C patients without anti\u2010CL. Serum triglyceride levels positively correlated with serum ApoB levels. CH\u2010C patients with anti\u2010CL had significantly more progressive hepatic fibrosis than those without anti\u2010CL. The degree of 8\u2010hydroxy 2\u2032\u2010deoxyguanosine (8\u2010OHdG) expression in the liver tissue was more severe in CH\u2010C patients with anti\u2010CL than in those without it. However, the emergence of anti\u2010CL in CH\u2010C patients was independent of insulin resistance, hepatic steatosis, and iron overload. These findings suggest that the emergence of anti\u2010CL is associated with oxidative stress and that CH\u2010C patients seropositive for anti\u2010CL have clinical characteristics of hypertriglyceridemia, which derives from the facilitation of ApoB synthesis, and progressive hepatic fibrosis. J. Clin. Lab. Anal. 26:342\u2010348, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jcla.21529","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T16:05:00Z","timestamp":1348243500000},"page":"342-348","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Relevance of Antibodies to Cardiolipin in Patients with Chronic Hepatitis <scp>C<\/scp>"],"prefix":"10.1002","volume":"26","author":[{"given":"Takashi","family":"Himoto","sequence":"first","affiliation":[{"name":"Department of Integrated Medicine Kagawa University School of Medicine  Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Neurology Kagawa University School of Medicine  Kagawa 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