{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:33:50Z","timestamp":1775129630213,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) is associated with high cardiovascular morbidity. The aim of the present study was to explore the relationship of leptin and adiponectin levels with cardiovascular risk factors and anthropometric parameters in patients with <jats:styled-content style=\"fixed-case\">PHTP<\/jats:styled-content> with and without metabolic syndrome (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 62 patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> were enrolled. Weight, blood pressure, basal glucose, insulin, total cholesterol, low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol, triglycerides, insulin, <jats:styled-content style=\"fixed-case\">HOMA\u2010R<\/jats:styled-content>, intact parathormone, vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>, calcium, leptin, and adiponectin levels were measured in fasting condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">ATP<\/jats:styled-content> III definition was 32.3% (20 patients; 15 females (75%) and 5 males (25%)) and 67.7% patients without <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> (<jats:italic>n<\/jats:italic> = 42 patients; 35 females (83.3%) and 7 males (16.7%)). In the analysis with leptin as dependent variable, the weight and <jats:styled-content style=\"fixed-case\">HOMA\u2010R<\/jats:styled-content> levels remained in the model (<jats:italic>F<\/jats:italic> = 9.2; <jats:italic>P<\/jats:italic> &lt; 0.05), with an increase of 1.31 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95%: 0.24\u20132.31) ng\/ml with each one unit of <jats:styled-content style=\"fixed-case\">HOMA\u2010R<\/jats:styled-content> and an increase of 0.4 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95%: 0.01\u20130.84) ng\/ml with each 1 kg of weight. In a second model with adiponectin as dependent variable, the <jats:styled-content style=\"fixed-case\">HOMA\u2010R<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010cholesterol levels remained in the model (<jats:italic>F<\/jats:italic> = 7.37; <jats:italic>P<\/jats:italic> &lt; 0.05), with a decrease of \u22120.62 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95%: 0.01\u20131.1) ng\/ml with each one point of <jats:styled-content style=\"fixed-case\">HOMA\u2010R<\/jats:styled-content> and an increase of 0.18 (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 95%: 0.04\u20130.38) ng\/ml with each 1 mg\/dl of <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010cholesterol. In the multivariate, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> I was not associated with other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a high prevalence of <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>\u201432.3% of patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> presented an <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Serum levels of leptin and adiponectin are not related with <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> I, vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>, and calcium levels in patients with <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>. J. Clin. Lab. Anal. 26:398\u2010402, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21541","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T16:05:00Z","timestamp":1348243500000},"page":"398-402","source":"Crossref","is-referenced-by-count":16,"title":["Relation of Leptin and Adiponectin With Cardiovascular Risk Factors, Intact Parathormone, and Vitamin <scp>D<\/scp> Levels in Patients With Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"26","author":[{"given":"Daniel Antonio","family":"de Luis","sequence":"first","affiliation":[{"name":"Center of Investigation of Endocrinology and Clinical Nutrition Medicine School and Unit of Investigation Hospital Rio Hortega University of Valladolid  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo Diaz","family":"Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Conde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olatz","family":"Izaola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"de la Fuente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206083200"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000048856.22331.50"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/43448"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.08.019"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199204000-00002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1998.00289.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.07.010"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001907"},{"issue":"19","key":"e_1_2_5_10_1","first-page":"2486","article-title":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults: Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","volume":"285","year":"2001","journal-title":"(Adult Treatment Panel III). 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