{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T13:09:49Z","timestamp":1723381789223},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Red cell distribution width (<jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content>) has been shown as a distinctive marker of mortality and morbidity in a wide spectrum of conditions related to systemic inflammation or deficiency of antioxidant nutrients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate the predictive value of <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> in detection of intestinal atrophy in celiac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Iron indices and <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> were studied in 49 patients with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> to evaluate the utilization of <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> as a predictive marker for presence of intestinal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine percent of patients had iron deficiency at initial presentation and 89% had abnormal <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> defined as &gt;14. Receiver operating characteristics curves of <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> has been found to be a predictive of intestinal atrophy at levels higher than 17.25 (68% sensitivity and 85% specificity). In patients with transglutaminase antibody <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> titers &gt;200 U\/l, <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> level &gt;17.75 showed 76% sensitivity and 100% specificity for intestinal atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We suggest that <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> can be used as a surrogate marker of atrophy in patients with iron deficiency and suspected <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. In addition, the sensitivity, specificity, negative and positive predictive values of <jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content> increases when used in combination with high levels of transglutaminase <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> antibody.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.21553","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T23:23:15Z","timestamp":1352503395000},"page":"497-502","source":"Crossref","is-referenced-by-count":13,"title":["Red Cell Distribution Width Can Predict Intestinal Atrophy in Selected Patients With Celiac Disease"],"prefix":"10.1002","volume":"26","author":[{"given":"Ozgur","family":"Harmanci","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hacettepe University Faculty of Medicine Sihhiye Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylan","family":"Kav","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hacettepe University Faculty of Medicine Sihhiye Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bulent","family":"Sivri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hacettepe University Faculty of Medicine Sihhiye Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,9]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"BaiJZE FriedM CorazzaGR et al.World Gastroenterology Organisation Practice Guidelines: Celiac Disease;2007. 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